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Changes in the interbranchial lymphoid tissue of Atlantic salmon (Salmo salar) affected by amoebic gill disease


Norte dos Santos, CC and Adams, MB and Leef, MJ and Nowak, BF, Changes in the interbranchial lymphoid tissue of Atlantic salmon (Salmo salar) affected by amoebic gill disease, Fish and Shellfish Immunology, 41, (2) pp. 600-607. ISSN 1050-4648 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.fsi.2014.10.003


The interbranchial lymphoid tissue (ILT) was recently described in the gills of salmonids. This study examined changes in the ILT during a parasitic infection in marine environment, using amoebic gill disease (AGD) as a model. Atlantic salmon (Salmo salar) experimentally infected with Neoparamoeba perurans were sampled at 0, 3, 7, 14 and 28 days post challenge. Transversal sections of three areas of the gills (dorsal, medial and ventral) were histologically assessed for morphological and cellular changes. AGD induced morphological changes and a cellular response in the ILT of affected fish. These changes included a significant increase in the ILT surface area in fish 28 days after AGD challenge, compared to control fish at the same time point. The length of the ILT increased significantly 28 days post exposure in the dorsal area of the gill arch in the fish affected by AGD. The lymphocyte density of the ILT increased after AGD challenge, peaking at 7 days post exposure; however, by 28 days post exposure, a reduction of lymphocyte density to values close to pre-infection levels was observed. PCNA immunostaining revealed that epithelial hyperplasia was the most likely factor contributing to the ILT enlargement in the affected fish.

Item Details

Item Type:Refereed Article
Keywords:interbranchial lymphoid tissue, ILT, gill-associated lymphoid tissue, Neoparamoeba perurans, AGD
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Fisheries sciences
Research Field:Aquaculture
Objective Division:Animal Production and Animal Primary Products
Objective Group:Fisheries - aquaculture
Objective Field:Aquaculture fin fish (excl. tuna)
UTAS Author:Norte dos Santos, CC (Miss Caterina Norte dos Santos)
UTAS Author:Adams, MB (Dr Mark Adams)
UTAS Author:Leef, MJ (Dr Melanie Leef)
UTAS Author:Nowak, BF (Professor Barbara Nowak)
ID Code:96883
Year Published:2014
Web of Science® Times Cited:6
Deposited By:NC Marine Conservation and Resource Sustainability
Deposited On:2014-11-25
Last Modified:2017-11-04

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