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Arrhythmogenicity of hypothermia - a large animal model of hypothermia
Citation
Bassin, L and Yong, AC and Kilpatrick, D and Hunyor, SN, Arrhythmogenicity of hypothermia - a large animal model of hypothermia, Heart, Lung and Circulation, 23, (1) pp. 82-87. ISSN 1443-9506 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 Elsevier
DOI: doi:10.1016/j.hlc.2013.07.001
Abstract
Methods: Ten sheep underwent systemic hypothermia using a venous-venous extra-corporeal circuit whilst instrumented with a 12 lead ECG. An epicardial sock recorded potentials to 30°C (n = 10) or 26°C (n = 6). Activation times (AT) and Activation Recovery Intervals (ARI) were calculated using custom software.
Results: The AT and ARI were significantly prolonged with increased heterogeneity during hypothermia. This effect was most pronounced between normothermia and 34°C during sinus rhythm (SR). For ventricular pacing (VP) however heterogeneity continued to increase with progressive hypothermia.
Conclusions: Hypothermia causes a significant increase in the heterogeneity of depolarisation and repolarisation. There is evidence to suggest that SR is protective with most of the increase in heterogeneity occurring with cooling to 34°C. This raises the possibility that the current target temperatures for therapeutic hypothermia may be safely lowered to provide a gain in cerebral protection.
Item Details
Item Type: | Refereed Article |
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Keywords: | hypothermia, therapeutic hypothermia, cardiac arrhythmias, cardiac electrophysiology |
Research Division: | Health Sciences |
Research Group: | Health services and systems |
Research Field: | Health services and systems not elsewhere classified |
Objective Division: | Health |
Objective Group: | Other health |
Objective Field: | Other health not elsewhere classified |
UTAS Author: | Yong, AC (Dr Ah Chot Yong) |
UTAS Author: | Kilpatrick, D (Professor David Kilpatrick) |
ID Code: | 96637 |
Year Published: | 2014 |
Web of Science® Times Cited: | 6 |
Deposited By: | Medicine |
Deposited On: | 2014-11-13 |
Last Modified: | 2017-11-01 |
Downloads: | 0 |
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