Bassin, L and Yong, AC and Kilpatrick, D and Hunyor, SN, Arrhythmogenicity of hypothermia - a large animal model of hypothermia, Heart, Lung and Circulation, 23, (1) pp. 82-87. ISSN 1443-9506 (2014) [Refereed Article]
Copyright 2014 Elsevier
Methods: Ten sheep underwent systemic hypothermia using a venous-venous extra-corporeal circuit whilst instrumented with a 12 lead ECG. An epicardial sock recorded potentials to 30°C (n = 10) or 26°C (n = 6). Activation times (AT) and Activation Recovery Intervals (ARI) were calculated using custom software.
Results: The AT and ARI were significantly prolonged with increased heterogeneity during hypothermia. This effect was most pronounced between normothermia and 34°C during sinus rhythm (SR). For ventricular pacing (VP) however heterogeneity continued to increase with progressive hypothermia.
Conclusions: Hypothermia causes a significant increase in the heterogeneity of depolarisation and repolarisation. There is evidence to suggest that SR is protective with most of the increase in heterogeneity occurring with cooling to 34°C. This raises the possibility that the current target temperatures for therapeutic hypothermia may be safely lowered to provide a gain in cerebral protection.
|Item Type:||Refereed Article|
|Keywords:||hypothermia, therapeutic hypothermia, cardiac arrhythmias, cardiac electrophysiology|
|Research Division:||Medical and Health Sciences|
|Research Group:||Other Medical and Health Sciences|
|Research Field:||Medical and Health Sciences not elsewhere classified|
|Objective Group:||Other Health|
|Objective Field:||Health not elsewhere classified|
|Author:||Yong, AC (Dr Ah Chot Yong)|
|Author:||Kilpatrick, D (Professor David Kilpatrick)|
|Web of Science® Times Cited:||4|
|Deposited By:||Medicine (Discipline)|
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