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Arrhythmogenicity of hypothermia - a large animal model of hypothermia


Bassin, L and Yong, AC and Kilpatrick, D and Hunyor, SN, Arrhythmogenicity of hypothermia - a large animal model of hypothermia, Heart, Lung and Circulation, 23, (1) pp. 82-87. ISSN 1443-9506 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.hlc.2013.07.001


Therapeutic hypothermia (TH) is used to mitigate cerebral injury after an out of hospital cardiac arrest. There is a perceived risk of increased arrhythmias with temperatures lower than the current target of 32-34C for TH. This study sought to develop and investigate the electrophysiological changes in a sheep model of systemic hypothermia regarding the susceptibility to ventricular arrhythmias.

Methods: Ten sheep underwent systemic hypothermia using a venous-venous extra-corporeal circuit whilst instrumented with a 12 lead ECG. An epicardial sock recorded potentials to 30C (n = 10) or 26C (n = 6). Activation times (AT) and Activation Recovery Intervals (ARI) were calculated using custom software.

Results: The AT and ARI were significantly prolonged with increased heterogeneity during hypothermia. This effect was most pronounced between normothermia and 34C during sinus rhythm (SR). For ventricular pacing (VP) however heterogeneity continued to increase with progressive hypothermia.

Conclusions: Hypothermia causes a significant increase in the heterogeneity of depolarisation and repolarisation. There is evidence to suggest that SR is protective with most of the increase in heterogeneity occurring with cooling to 34C. This raises the possibility that the current target temperatures for therapeutic hypothermia may be safely lowered to provide a gain in cerebral protection.

Item Details

Item Type:Refereed Article
Keywords:hypothermia, therapeutic hypothermia, cardiac arrhythmias, cardiac electrophysiology
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Health services and systems not elsewhere classified
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Yong, AC (Dr Ah Chot Yong)
UTAS Author:Kilpatrick, D (Professor David Kilpatrick)
ID Code:96637
Year Published:2014
Web of Science® Times Cited:6
Deposited By:Medicine
Deposited On:2014-11-13
Last Modified:2017-11-01

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