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Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomized controlled pilot study

Citation

Cunningham, DJ and Brimage, JT and Naraghi, RN and Bower, VM, Needling versus liquid nitrogen cryotherapy for the treatment of pedal warts: A randomized controlled pilot study, Journal of the American Podiatric Medical Association, 104, (4) pp. 394-401. ISSN 8750-7315 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 American Podiatric Medical Association

DOI: doi:10.7547/0003-0538-104.4.394

Abstract

Background: We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective was to investigate whether the CMIR induced by needling is effective against satellite pedal warts.

Methods: Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances.

Results: Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression of the primary pedal wart occurred in 64.7% of the needling group (11 of 17) and in 6.2% of the liquid nitrogen cryotherapy group (1 of 16) (P = .001). No significant relationship was found between needling of the primary pedal wart and regression of satellite pedal warts (P = .615) or complete pedal wart regression (P = .175). There was no significant difference in pain, satisfaction, or cosmesis between the two groups.

Conclusions: The regression rate of the primary pedal wart was significantly higher in the needling group compared with the liquid nitrogen cryotherapy group.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Podiatry
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Bower, VM (Ms Virginia Bower)
ID Code:96631
Year Published:2014
Web of Science® Times Cited:1
Deposited By:Medicine (Discipline)
Deposited On:2014-11-13
Last Modified:2015-06-09
Downloads:0

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