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Microfluidic culture platform for studying neuronal response to axonal stretch injury

Citation

Yap, YC and Dickson, TC and King, AE and Breadmore, MC and Guijt, RM, Microfluidic culture platform for studying neuronal response to axonal stretch injury, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, October 28 - November 1, 2012, Okinawa, Japan, pp. 1-13. ISSN 1932-1058 (2012) [Refereed Conference Paper]

Copyright Statement

Copyright 2014 American Institute of Physics

DOI: doi:10.1063/1.4891098

Abstract

We have developed novel device where a localised axonal stretch injury is achieved by the integration of a pressure-flexible valve in the axon compartment of a fluidically isolated neuron culture device. Defined stretch injuries applied using this device resulted in delayed neuronal alterations typical of those observed in vivo. These results confirm the suitability of this system for studying the neuronal response to axonal stretch injury. Therefore, this system provides a valuable tool for studying the degenerative and regenerative neuronal responses induced by acute stretch injury and provides a suitable platform for testing potential therapeutic agents.

Item Details

Item Type:Refereed Conference Paper
Keywords:microfluidic, lab on a chip, axon stretch injury, PDMS device for cell culture, neuroscience, neuron culture, traumatic brain injury
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Yap, YC (Dr Yiing Yap)
Author:Dickson, TC (Associate Professor Tracey Dickson)
Author:King, AE (Associate Professor Anna King)
Author:Breadmore, MC (Professor Michael Breadmore)
Author:Guijt, RM (Dr Rosanne Guijt)
ID Code:96620
Year Published:2012
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2014-11-13
Last Modified:2017-11-07
Downloads:0

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