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Microfluidic culture platform for studying neuronal response to axonal stretch injury
conference contribution
posted on 2023-05-24, 13:07 authored by Ying YapYing Yap, Tracey DicksonTracey Dickson, Anna KingAnna King, Michael BreadmoreMichael Breadmore, Rosanne GuijtWe have developed novel device where a localised axonal stretch injury is achieved by the integration of a pressure-flexible valve in the axon compartment of a fluidically isolated neuron culture device. Defined stretch injuries applied using this device resulted in delayed neuronal alterations typical of those observed in vivo. These results confirm the suitability of this system for studying the neuronal response to axonal stretch injury. Therefore, this system provides a valuable tool for studying the degenerative and regenerative neuronal responses induced by acute stretch injury and provides a suitable platform for testing potential therapeutic agents.
Funding
University of Tasmania
History
Publication title
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life SciencesVolume
8Editors
H-C Chang & LY YeoPagination
1-13ISSN
1932-1058Department/School
School of Natural SciencesPublisher
American Institute of PhysicsPlace of publication
United StatesEvent title
16th International Conference on Miniaturized Systems for Chemistry and Life SciencesEvent Venue
Okinawa, JapanDate of Event (Start Date)
2012-10-28Date of Event (End Date)
2012-01-01Rights statement
Copyright 2014 American Institute of PhysicsRepository Status
- Restricted