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Relationship between cotinine and trans-3' -hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers
Jacobson, GA and Ferguson, SG, Relationship between cotinine and trans-3' -hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers, Biomarkers, 19, (8) pp. 679-683. ISSN 1366-5804 (2014) [Refereed Article]
Copyright 2014 Informa UK Ltd.
Context: Nicotine metabolite ratio (NMR) is linked with smoking behaviour and quitting, but little is known about the importance of UDP-glucuronosyltransferase metabolism phenotype on NMR.
Objective: To investigate the relationship between NMR and UDP-glucuronosyltransferase phenotype in a Caucasian population.
Methods: Urine samples from 260 smokers were measured by UPLC-MS/MS for cotinine (COT), 30-hydroxycotinine, COT-glucuronide and 30-hydroxycotinine-glucuronide. UDP-glucuronosyltransferase phenotype was assessed using the proportion of metabolites present as the glucuronide.
Results: A correlation was found between NMR and UDP-glucuronosyltransferase phenotype for COT (males and females) and 3′-HC in females (p < 0.0001).
Conclusion: NMR is clearly influenced by UDP-glucuronosyltransferase phenotype for COT in Caucasians.
|Item Type:||Refereed Article|
|Keywords:||genotype, nicotine metabolite ratio, smoking cessation|
|Research Division:||Health Sciences|
|Research Group:||Public health|
|Research Field:||Preventative health care|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Public health (excl. specific population health) not elsewhere classified|
|UTAS Author:||Jacobson, GA (Professor Glenn Jacobson)|
|UTAS Author:||Ferguson, SG (Professor Stuart Ferguson)|
|Funding Support:||National Health and Medical Research Council (1002874)|
|Web of Science® Times Cited:||5|
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