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Relationship between cotinine and trans-3' -hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers

journal contribution
posted on 2023-05-18, 05:02 authored by Glenn JacobsonGlenn Jacobson, Stuart FergusonStuart Ferguson

Context: Nicotine metabolite ratio (NMR) is linked with smoking behaviour and quitting, but little is known about the importance of UDP-glucuronosyltransferase metabolism phenotype on NMR.

Objective: To investigate the relationship between NMR and UDP-glucuronosyltransferase phenotype in a Caucasian population.

Methods: Urine samples from 260 smokers were measured by UPLC-MS/MS for cotinine (COT), 30-hydroxycotinine, COT-glucuronide and 30-hydroxycotinine-glucuronide. UDP-glucuronosyltransferase phenotype was assessed using the proportion of metabolites present as the glucuronide.

Results: A correlation was found between NMR and UDP-glucuronosyltransferase phenotype for COT (males and females) and 3′-HC in females (p < 0.0001).

Conclusion: NMR is clearly influenced by UDP-glucuronosyltransferase phenotype for COT in Caucasians.

Funding

National Health & Medical Research Council

History

Publication title

Biomarkers

Volume

19

Issue

8

Pagination

679-683

ISSN

1366-5804

Department/School

School of Pharmacy and Pharmacology

Publisher

Informa Healthcare

Place of publication

United Kingdom

Rights statement

Copyright 2014 Informa UK Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Public health (excl. specific population health) not elsewhere classified

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