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Relationship between cotinine and trans-3' -hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers
Citation
Jacobson, GA and Ferguson, SG, Relationship between cotinine and trans-3' -hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers, Biomarkers, 19, (8) pp. 679-683. ISSN 1366-5804 (2014) [Refereed Article]
Copyright Statement
Copyright 2014 Informa UK Ltd.
DOI: doi:10.3109/1354750X.2014.966254
Abstract
Context: Nicotine metabolite ratio (NMR) is linked with smoking behaviour and quitting, but little is known about the importance of UDP-glucuronosyltransferase metabolism phenotype on NMR.
Objective: To investigate the relationship between NMR and UDP-glucuronosyltransferase phenotype in a Caucasian population.
Methods: Urine samples from 260 smokers were measured by UPLC-MS/MS for cotinine (COT), 30-hydroxycotinine, COT-glucuronide and 30-hydroxycotinine-glucuronide. UDP-glucuronosyltransferase phenotype was assessed using the proportion of metabolites present as the glucuronide.
Results: A correlation was found between NMR and UDP-glucuronosyltransferase phenotype for COT (males and females) and 3′-HC in females (p < 0.0001).
Conclusion: NMR is clearly influenced by UDP-glucuronosyltransferase phenotype for COT in Caucasians.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | genotype, nicotine metabolite ratio, smoking cessation |
| Research Division: | Health Sciences |
| Research Group: | Public health |
| Research Field: | Preventative health care |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Public health (excl. specific population health) not elsewhere classified |
| UTAS Author: | Jacobson, GA (Professor Glenn Jacobson) |
| UTAS Author: | Ferguson, SG (Professor Stuart Ferguson) |
| ID Code: | 96495 |
| Year Published: | 2014 |
| Funding Support: | National Health and Medical Research Council (1002874) |
| Web of Science® Times Cited: | 5 |
| Deposited By: | Pharmacy |
| Deposited On: | 2014-11-07 |
| Last Modified: | 2017-11-07 |
| Downloads: | 0 |
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