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Relationship between cotinine and trans-3' -hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers

Citation

Jacobson, GA and Ferguson, SG, Relationship between cotinine and trans-3' -hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers, Biomarkers, 19, (8) pp. 679-683. ISSN 1366-5804 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Informa UK Ltd.

DOI: doi:10.3109/1354750X.2014.966254

Abstract

Context: Nicotine metabolite ratio (NMR) is linked with smoking behaviour and quitting, but little is known about the importance of UDP-glucuronosyltransferase metabolism phenotype on NMR.

Objective: To investigate the relationship between NMR and UDP-glucuronosyltransferase phenotype in a Caucasian population.

Methods: Urine samples from 260 smokers were measured by UPLC-MS/MS for cotinine (COT), 30-hydroxycotinine, COT-glucuronide and 30-hydroxycotinine-glucuronide. UDP-glucuronosyltransferase phenotype was assessed using the proportion of metabolites present as the glucuronide.

Results: A correlation was found between NMR and UDP-glucuronosyltransferase phenotype for COT (males and females) and 3′-HC in females (p < 0.0001).

Conclusion: NMR is clearly influenced by UDP-glucuronosyltransferase phenotype for COT in Caucasians.

Item Details

Item Type:Refereed Article
Keywords:genotype, nicotine metabolite ratio, smoking cessation
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Preventive Medicine
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Substance Abuse
Author:Jacobson, GA (Dr Glenn Jacobson)
Author:Ferguson, SG (Associate Professor Stuart Ferguson)
ID Code:96495
Year Published:2014
Funding Support:National Health and Medical Research Council (1002874)
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2014-11-07
Last Modified:2017-11-07
Downloads:0

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