Hewitt, AW and Cooper, RL, Relationship between corneal thickness and optic disc damage in glaucoma, Clinical and Experimental Ophthalmology, 33, (2) pp. 158-163. ISSN 1442-6404 (2005) [Refereed Article]
METHODS: The vertical cup/disc ratio (VCDR) was used as a single objective measure of glaucoma severity. Vertical cup diameters and vertical disc diameters were measured using a graticule attached to a 60 D Volk lens, in consecutive patients presenting to a single ophthalmologist. Measurements were corrected for magnification. The difference between corrected VCDR and 95% probability of VCDR normality was compared to CCT, which was measured with an ultrasonic pachymeter.
RESULTS: During the study period 554 eyes from 281 patients with glaucoma were reviewed. The mean CCT was 519.0 microm, with the mean corrected VCDR being 0.71. A univariate linear regression model revealed that an increase of 10 microm in CCT resulted in a 0.009 decrease in the difference between true VCDR and the predicted normal VCDR. The R2 value for the regression was 0.04 (P < 0.0001).
CONCLUSION: There is a highly statistically significant, albeit small, negative correlation between corneal thickness and glaucoma severity. This study supports the notion that CCT should be measured in the assessment of patients with glaucoma. Progressive thinning or presence of a thin cornea may have pathogenic or prognostic roles in some types of glaucoma.
|Item Type:||Refereed Article|
|Keywords:||central corneal thickness, cup to disc ratio, glaucoma, optic disc cup, severity|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Ophthalmology and optometry|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Hewitt, AW (Professor Alex Hewitt)|
|Web of Science® Times Cited:||22|
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