Hawrelak, JA and Whitten, DL and Myers, SP, Is Lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhoea: a systematic review, Digestion: International Journal of Gastroenterology, 72, (1) pp. 51-56. ISSN 0012-2823 (2005) [Refereed Article]
OBJECTIVE: To evaluate the efficacy of Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea.
DATA SOURCES: A computer-based search of MEDLINE, CINAHL, AMED, the Cochrane Controlled Trials Register and the Cochrane Database of Systematic Reviews was conducted. A hand-search of the bibliographies of relevant papers and previous meta-analyses was undertaken.
REVIEW METHODS: Trials were included in the review if they compared the effects of L. rhamnosus GG and placebo and listed diarrhoea as a primary end-point. Studies were excluded if they were not placebo-controlled or utilised other probiotic strains.
RESULTS: Six trials were found that met all eligibility requirements. Significant statistical heterogeneity of the trials precluded meta-analysis. Four of the six trials found a significant reduction in the risk of antibiotic-associated diarrhoea with co-administration of Lactobacillus GG. One of the trials found a reduced number of days with antibiotic-induced diarrhoea with Lactobacillus GG administration, whilst the final trial found no benefit of Lactobacillus GG supplementation.
CONCLUSION: Additional research is needed to further clarify the effectiveness of Lactobacillus GG in the prevention of antibiotic-associated diarrhoea.
|Item Type:||Refereed Article|
|Keywords:||Antibiotic-associated diarrhea; Antibiotics; Lactobacillus rhamnosus; Probiotics|
|Research Division:||Medical and Health Sciences|
|Research Group:||Complementary and Alternative Medicine|
|Research Field:||Complementary and Alternative Medicine not elsewhere classified|
|Objective Division:||Expanding Knowledge|
|Objective Group:||Expanding Knowledge|
|Objective Field:||Expanding Knowledge in the Medical and Health Sciences|
|Author:||Hawrelak, JA (Dr Jason Hawrelak)|
|Web of Science® Times Cited:||53|
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