eCite Digital Repository
Is Lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhoea: a systematic review
Citation
Hawrelak, JA and Whitten, DL and Myers, SP, Is Lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhoea: a systematic review, Digestion: International Journal of Gastroenterology, 72, (1) pp. 51-56. ISSN 0012-2823 (2005) [Refereed Article]
Abstract
OBJECTIVE: To evaluate the efficacy of Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea.
DATA SOURCES: A computer-based search of MEDLINE, CINAHL, AMED, the Cochrane Controlled Trials Register and the Cochrane Database of Systematic Reviews was conducted. A hand-search of the bibliographies of relevant papers and previous meta-analyses was undertaken.
REVIEW METHODS: Trials were included in the review if they compared the effects of L. rhamnosus GG and placebo and listed diarrhoea as a primary end-point. Studies were excluded if they were not placebo-controlled or utilised other probiotic strains.
RESULTS: Six trials were found that met all eligibility requirements. Significant statistical heterogeneity of the trials precluded meta-analysis. Four of the six trials found a significant reduction in the risk of antibiotic-associated diarrhoea with co-administration of Lactobacillus GG. One of the trials found a reduced number of days with antibiotic-induced diarrhoea with Lactobacillus GG administration, whilst the final trial found no benefit of Lactobacillus GG supplementation.
CONCLUSION: Additional research is needed to further clarify the effectiveness of Lactobacillus GG in the prevention of antibiotic-associated diarrhoea.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Antibiotic-associated diarrhea; Antibiotics; Lactobacillus rhamnosus; Probiotics |
Research Division: | Health Sciences |
Research Group: | Traditional, complementary and integrative medicine |
Research Field: | Traditional, complementary and integrative medicine not elsewhere classified |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the health sciences |
UTAS Author: | Hawrelak, JA (Dr Jason Hawrelak) |
ID Code: | 96454 |
Year Published: | 2005 |
Web of Science® Times Cited: | 69 |
Deposited By: | Pharmacy |
Deposited On: | 2014-11-06 |
Last Modified: | 2014-11-06 |
Downloads: | 0 |
Repository Staff Only: item control page