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Is Lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhoea: a systematic review

Citation

Hawrelak, JA and Whitten, DL and Myers, SP, Is Lactobacillus rhamnosus GG effective in preventing the onset of antibiotic-associated diarrhoea: a systematic review, Digestion: International Journal of Gastroenterology, 72, (1) pp. 51-56. ISSN 0012-2823 (2005) [Refereed Article]

DOI: doi:10.1159/000087637

Abstract

OBJECTIVE: To evaluate the efficacy of Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea.

DATA SOURCES: A computer-based search of MEDLINE, CINAHL, AMED, the Cochrane Controlled Trials Register and the Cochrane Database of Systematic Reviews was conducted. A hand-search of the bibliographies of relevant papers and previous meta-analyses was undertaken.

REVIEW METHODS: Trials were included in the review if they compared the effects of L. rhamnosus GG and placebo and listed diarrhoea as a primary end-point. Studies were excluded if they were not placebo-controlled or utilised other probiotic strains.

RESULTS: Six trials were found that met all eligibility requirements. Significant statistical heterogeneity of the trials precluded meta-analysis. Four of the six trials found a significant reduction in the risk of antibiotic-associated diarrhoea with co-administration of Lactobacillus GG. One of the trials found a reduced number of days with antibiotic-induced diarrhoea with Lactobacillus GG administration, whilst the final trial found no benefit of Lactobacillus GG supplementation.

CONCLUSION: Additional research is needed to further clarify the effectiveness of Lactobacillus GG in the prevention of antibiotic-associated diarrhoea.

Item Details

Item Type:Refereed Article
Keywords:Antibiotic-associated diarrhea; Antibiotics; Lactobacillus rhamnosus; Probiotics
Research Division:Medical and Health Sciences
Research Group:Complementary and Alternative Medicine
Research Field:Complementary and Alternative Medicine not elsewhere classified
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Hawrelak, JA (Dr Jason Hawrelak)
ID Code:96454
Year Published:2005
Web of Science® Times Cited:53
Deposited By:Pharmacy
Deposited On:2014-11-06
Last Modified:2014-11-06
Downloads:0

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