eCite Digital Repository

Translating the ENCyclopedia Of DNA Elements Project findings to the clinic: ENCODE's implications for eye disease

Citation

Sanfilippo, PG and Hewitt, AW, Translating the ENCyclopedia Of DNA Elements Project findings to the clinic: ENCODE's implications for eye disease, Clinical and Experimental Ophthalmology, 42, (1) pp. 78-83. ISSN 1442-6404 (2014) [Refereed Article]

DOI: doi:10.1111/ceo.12150

Abstract

Approximately 10 years after the Human Genome Project unravelled the sequence of our DNA, the ENCyclopedia Of DNA Elements (ENCODE) Project sought to interpret it. Data from the recently completed project have shed new light on the proportion of biologically active human DNA, assigning a biochemical role to much of the sequence previously considered to be 'junk'. Many of these newly catalogued functional elements represent epigenetic mechanisms involved in regulation of gene expression. Analogous to an Ishihara plate, a gene-coding region of DNA (target dots) only comes into context when the non-coding DNA (surrounding dots) is appreciated. In this review we provide an overview of the ENCODE project, discussing the significance of these data for ophthalmic research and eye disease. The novel insights afforded by the ENCODE project will in time allow for the development of new therapeutic strategies in the management of common blinding disorders.

Item Details

Item Type:Refereed Article
Keywords:epigenetic, glaucoma, macular degeneration, methylation, myopia
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Hewitt, AW (Dr Alex Hewitt)
ID Code:96453
Year Published:2014
Web of Science® Times Cited:1
Deposited By:Medicine (Discipline)
Deposited On:2014-11-06
Last Modified:2017-11-07
Downloads:0

Repository Staff Only: item control page