Dunstan, E and Lester, S and Rischmueller, M and Chan, H and Hewitt, AW and Hill, C, TLR4 polymorphism is not associated with biopsy proven giant cell arteritis, Clinical and Experimental Rheumatology, 32, (Suppl. 82) pp. S26-S29. ISSN 0392-856X (2014) [Refereed Article]
Methods: A case-control genetic study was performed using DNA from Australian biopsy proven GCA patients (n=139) and population controls (n=130). Samples were genotyped for 8 SNPs tagging common variation across TLR4. These SNPs included rs4986790 (+896A/G, Asp299Gly) and rs4986791 (+1196C/T) which have been previously studied in GCA. Allelic and haplotypic variation was analysed by logistic regression assuming an additive genetic model. A random effects meta-analysis of the association between GCA and rs4986790 was performed utilising data from three previous studies.
Results: rs4986790 and rs4986791 are in strong linkage disequilbrium and tag one of the five common TLR4 haplotypes identified. No associations were observed between TLR4 SNPs and/or haplotypes and GCA. A meta-analysis, comprising 577 GCA patients and 1153 controls, did not confirm an association between GCA and rs4986790 (OR 1.29, 95% CI 0.86, 1.92, p=0.22).
Conclusion: There is no evidence of an association between TLR4 polymorphism and susceptibility to GCA.
|Item Type:||Refereed Article|
|Keywords:||Case-control studies; Giant cell arteritis; Polymorphism; Vasculitis|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Ophthalmology and optometry|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Hewitt, AW (Professor Alex Hewitt)|
|Web of Science® Times Cited:||4|
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