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A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study

Citation

Blackburn, NB and Charlesworth, JC and Marthick, JR and Tegg, EM and Marsden, KA and Srikanth, V and Blangero, J and Lowenthal, RM and Foote, SJ and Dickinson, JL, A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study, Oncology Reports, 33, (1) pp. 25-32. ISSN 1791-2431 (2015) [Refereed Article]

Copyright Statement

Copyright 2014 Oncology Reports

DOI: doi:10.3892/or.2014.3568

Abstract

Telomere length has a biological link to cancer, with excessive telomere shortening leading to genetic instability and resultant malignant transformation. Telomere length is heritable and genetic variants determining telomere length have been identified. Telomere biology has been implicated in the development of hematological malignancies (HMs), therefore, closer examination of telomere length in HMs may provide further insight into genetic etiology of disease development and support for telomere length as a prognostic factor in HMs. We retrospectively examined mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study using a quantitative PCR method on genomic DNA from peripheral blood samples. Fifty-five familial HM cases, 191 unaffected relatives of familial HM cases and 75 non-familial HM cases were compared with 758 population controls. Variance components modeling was employed to identify factors influencing variation in telomere length. Overall, HM cases had shorter mean relative telomere length (p=2.910-6) and this was observed across both familial and non-familial HM cases (p=2.2x10-4 and 2.2x10-5, respectively) as well as additional subgroupings of HM cases according to broad subtypes. Mean relative telomere length was also significantly heritable (62.6%; p=4.7x10-5) in the HM families in the present study. We present new evidence of significantly shorter mean relative telomere length in both familial and non-familial HM cases from the same population adding further support to the potential use of telomere length as a prognostic factor in HMs. Whether telomere shortening is the cause of or the result of HMs is yet to be determined, but as telomere length was found to be highly heritable in our HM families this suggests that genetics driving the variation in telomere length is related to HM disease risk.

Item Details

Item Type:Refereed Article
Keywords:telomere length, hematological malignancies, familial cancer
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Blackburn, NB (Mr Nicholas Blackburn)
Author:Charlesworth, JC (Dr Jac Charlesworth)
Author:Marthick, JR (Mr James Marthick)
Author:Tegg, EM (Dr Elizabeth Tegg)
Author:Marsden, KA (Dr Katherine Marsden)
Author:Lowenthal, RM (Professor Ray Lowenthal)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
ID Code:96399
Year Published:2015 (online first 2014)
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-11-04
Last Modified:2017-11-03
Downloads:0

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