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Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling


Walters, EH and Reid, DW and Johns, DP and Ward, C, Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling, European Respiratory Journal, 30, (3) pp. 574-588. ISSN 0903-1936 (2007) [Refereed Article]

DOI: doi:10.1183/09031936.00007306


In the present review of airway remodelling and its response to therapies, clinical observations about airway physiological abnormalities, assumed to be caused by remodelling processes, are related to what is known about the components of structural changes from airway sampling and histopathological analysis. The review focuses on three important diseases: asthma, chronic obstructive pulmonary disease and bronchiolitis obliterans syndrome (BOS), which occurs commonly after lung transplantation as a manifestation of chronic rejection. The present authors chose to use BOS as an issue, because with routine bronchoscopic surveillance after lung transplantation there has been more opportunity to directly study airway pathology longitudinally than in more everyday conditions. In addition, the present authors have reviewed animal models of induced airway remodelling, where most information is available on the potential of therapeutic intervention. Finally, the limited information that can be gained from the literature on the effects of commonly used airway medications on remodelling components is reviewed. In conclusion, the present authors have detailed some of the gaps in knowledge surrounding the potential to improve or modulate remodelling processes in human disease. The areas where it is believed urgent research needs to be focused have also been highlighted. Copyright©ERS Journals Ltd 2007.

Item Details

Item Type:Refereed Article
Keywords:Airways; Asthma; Bronchiolitis obliterans syndrome; Chronic obstructive pulmonary disease; Pharmacology; Remodelling
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Walters, EH (Professor Haydn Walters)
UTAS Author:Reid, DW (Dr David Reid)
UTAS Author:Johns, DP (Associate Professor David Johns)
UTAS Author:Ward, C (Dr Christopher Ward)
ID Code:96388
Year Published:2007
Web of Science® Times Cited:18
Deposited By:School of Medicine
Deposited On:2014-11-04
Last Modified:2014-11-04

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