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Aortic reservoir characteristics and brain structure in people with type 2 diabetes mellitus; a cross sectional study


Climie, RED and Srikanth, V and Beare, R and Keith, LJ and Fell, J and Davies, JE and Sharman, JE, Aortic reservoir characteristics and brain structure in people with type 2 diabetes mellitus; a cross sectional study, Cardiovascular Diabetology, 13, (1) Article 143. ISSN 1475-2840 (2014) [Refereed Article]


Copyright Statement

Copyright 2014 Climie et al-This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0).(, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

DOI: doi:10.1186/s12933-014-0143-6


Background: Central hemodynamics help to maintain appropriate cerebral and other end-organ perfusion, and may be altered with ageing and type 2 diabetes mellitus (T2DM). We aimed to determine the associations between central hemodynamics and brain structure at rest and during exercise in people with and without T2DM.

Methods: In a sample of people with T2DM and healthy controls, resting and exercise measures of aortic reservoir characteristics (including excess pressure integral [Pexcess]) and other central hemodynamics (including augmentation index [AIx] and aortic pulse wave velocity [aPWV]) were recorded. Brain volumes (including gray matter volume [GMV] and white matter lesions [WML]) were derived from magnetic resonance imaging (MRI) scans. Multivariable linear regression was used to study the associations of hemodynamic variables with brain structure in the two groups adjusting for age, sex, daytime systolic BP (SBP) and heart rate.ResultsThere were 37 T2DM (639 years; 47% male) and 37 healthy individuals (528 years; 51% male). In T2DM, resting aPWV was inversely associated with GMV (standardized ߿=0.47, p=0.036). In healthy participants, resting Pexcess was inversely associated with GMV (߿=0.23, p=0.043) and AIx was associated with WML volume (߿=0.52, p=0.021). There were no associations between exercise hemodynamics and brain volumes in either group.

Conclusions: Brain atrophy is associated with resting aortic stiffness in T2DM, and resting Pexcess in healthy individuals. Central vascular mechanisms underlying structural brain changes may differ between healthy individuals and T2DM.

Item Details

Item Type:Refereed Article
Keywords:Type 2 diabetes mellitus, Central hemodynamics, Aortic stiffness, Magnetic resonance imaging, Vascular cognitive impairment
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Climie, RED (Dr Rachel Climie)
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
UTAS Author:Keith, LJ (Miss Laura Keith)
UTAS Author:Fell, J (Associate Professor James Fell)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:96327
Year Published:2014
Web of Science® Times Cited:22
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-10-30
Last Modified:2017-11-06
Downloads:230 View Download Statistics

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