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Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population


Gao, L and Thakur, A and Liang, Y and Zhang, S and Wang, T and Chen, T and Meng, J and Wang, L and Wu, F and Jin, T and Li, X and Liu, JJ and Chen, C and Chen, M, Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population, European Journal of Cancer Prevention, 23, (6) pp. 497-501. ISSN 0959-8278 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

DOI: doi:10.1097/CEJ.0000000000000086


Lung cancer has the highest mortality rate among cancers; however, its nosogenesis is still unclear. Genome-wide association studies have shown that the telomerase reverse transcriptase (TERT) gene, located in the chromosome 5p15.33 region, is one of the genes associated with the risk of lung cancer. In this case–control study, we genotyped 11 tag single-nucleotide polymorphisms of the TERT gene to evaluate their association with lung cancer risk in the Han Chinese population. Two tag single-nucleotide polymorphisms were found to be associated with lung cancer risk on using the χ2-test: rs4246742 [odds ratio (OR) = 0.77, 95% confidence interval (CI) 0.60–0.98; P = 0.03] and rs2853672 (OR = 1.26, 95% CI 1.01–1.57; P = 0.045). By using SNPStats software we also found rs2242652 (OR = 1.47, 95% CI 1.02–2.13; P = 0.04) in the dominant model and rs2736098 (OR = 1.38, 95% CI 1.06–1.80; P = 0.017), rs2853672 (OR = 1.41, 95% CI 1.11–1.80; P = 0.0048), and rs4246742 (OR = 0.75, 95% CI 0.58–0.97; P = 0.029) in the log-additive model. ‘T/C-T/T’ of rs10069690 conferred an increased risk for male sex in the dominant model (OR = 1.80, 95% CI, 1.05–3.08; P = 0.03) and ‘TC’ increased risk for male sex in the overdominant model (OR = 1.85, 95% CI, 1.08–3.17; P = 0.031). Our findings, combined with previous studies, suggest that polymorphisms in the TERT gene contribute to the risk for lung cancer in the Chinese Han population.

Item Details

Item Type:Refereed Article
Keywords:case–control studies, lung cancer, tag single-nucleotide polymorphisms, TERT gene
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Liu, JJ (Dr Johnson Liu)
ID Code:96303
Year Published:2014
Web of Science® Times Cited:35
Deposited By:Pharmacy
Deposited On:2014-10-29
Last Modified:2017-11-02

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