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Health economics analysis of insulin aspart vs. regular human insulin in Type 2 Diabetes patients, based on observational real life evidence from general practices in Germany

Citation

Liebl, A and Seitz, L and Palmer, AJ, Health economics analysis of insulin aspart vs. regular human insulin in Type 2 Diabetes patients, based on observational real life evidence from general practices in Germany, Experimental and Clinical Endocrinology & Diabetes, 122, (9) pp. 517-522. ISSN 0947-7349 (2014) [Refereed Article]

DOI: doi:10.1055/s-0034-1376987

Abstract

Background: A retrospective analysis of German general practice data demonstrated that insulin aspart (IA) was associated with a significantly reduced incidence of macrovascular events (MVE: stroke, myocardial infarction, peripheral vascular disease or coronary heart disease) vs. regular human insulin (RHI) in type 2 diabetes patients. Economic implications, balanced against potential improvements in quality-adjusted life years (QALYs) resulting from lower risks of complications with IA in this setting have not yet been explored.

Methods: A decision analysis model was developed utilizing 3-year initial MVE rates for each comparator, combined with published German-specific insulin and MVE costs and health utilities to calculate number needed to treat (NNT) to avoid any MVE, incremental costs and QALYs gained/ person for IA vs. RHI. A 3-year time horizon and German 3rd-party payer perspective were used. Probabilistic sensitivity analysis was performed, sampling from distributions of key parameters. Additional sensitivity analyses were performed.

Results: NNT over a 3 year period to avoid any MVE was 8 patients for IA vs. RHI. Due to lower MVE rates, IA dominated RHI with 0.020 QALYs gained (95% confidence interval: 0.014-0.025) and cost savings of EUR 1 556 (1 062-2 076)/person for IA vs. RHI over the 3-year time horizon. Sensitivity analysis revealed that IA would still be overall cost saving even if the cost of IA was double the cost/unit of RHI.

Conclusions: From a health economics perspective, IA was the superior alternative for the insulin treatment of type 2 diabetes, with lower incidence of MVE events translating to improved QALYs and lower costs vs. RHI within a 3-year time horizon.

Item Details

Item Type:Refereed Article
Keywords:health economics, costs, insulin, Germany, diabetes, cardiovascular disease
Research Division:Economics
Research Group:Applied Economics
Research Field:Health Economics
Objective Division:Health
Objective Group:Health and Support Services
Objective Field:Evaluation of Health Outcomes
Author:Palmer, AJ (Professor Andrew Palmer)
ID Code:96292
Year Published:2014
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-10-29
Last Modified:2017-11-02
Downloads:0

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