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Emerging drug--resistance and guidelines for treatment of malaria


Khan, MA and Smego, RA Jr and Razi Zaidi, ST and Beg, MA, Emerging drug--resistance and guidelines for treatment of malaria, College of Physicians and Surgeons Pakistan. Journal, 14, (5) pp. 319-24. ISSN 1022-386X (2004) [Refereed Article]


The increasing prevalence of multi-resistant Plasmodium falciparum malaria worldwide is a serious public health threat to the global control of malaria, especially in poor countries like Pakistan. In many countries choloroquine-resistance is a huge problem, accounting for more than 90% of malaria cases. In Pakistan, resistance to choloroquin is on the rise and reported in up to 16- 62% of Plasmodium falciparum. four to 25% of Plasmodium falciparum also reported to be resistant to sulfadoxine-pyrimethamine and several cases of delayed parasite clearance have been observed in patients with Plasmodium falciparum malaria treated with quinine. In this article we have introduced the concept of artemisinin- based combination therapy (ACT) and emphasize the use of empiric combination therapy for all patients with Plasmodium falciparum malaria to prevent development of drug resistance and to obtain additive and synergistic killing of parasite.

Item Details

Item Type:Refereed Article
Keywords:malaria, resistance, guidelines, developing countries
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Razi Zaidi, ST (Dr Tabish Razi Zaidi)
ID Code:96282
Year Published:2004
Deposited By:Pharmacy
Deposited On:2014-10-29
Last Modified:2017-11-27

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