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Modulating effects of WT1 on interferon-β-vitamin D association in MS
Citation
Lin, R and Taylor, BV and Charlesworth, J and van der Mei, I and Blizzard, L and Stewart, N and Ponsonby, A-L and Dwyer, T and Pittas, F and Simpson JR, S, Modulating effects of WT1 on interferon-β-vitamin D association in MS, Acta Neurologica Scandinavica, 131, (4) pp. 231-239. ISSN 0001-6314 (2015) [Refereed Article]
Copyright Statement
Copyright 2014 Wiley-Blackwell
Abstract
Methods:Prospective cohort study of 169 participants with MS and genotype data followed 2002–2005. Gene-IFN-β and gene-IFN-β-sun interactions predicting 25(OH)D evaluated by multilevel mixed-effects linear regression. Gene-IFN-β interactions with 25(OH)D in modulating in relapse risk assessed using survival analysis.
Results:The cohort was 71.6% female and of mean age 47.8. Two-independent intronic genotyped SNPs (rs10767935 and rs5030244) in WT1 significantly modified the IFN-β-25(OH)D association after adjustment (Pinteraction = 0.001, 0.0002; Padj = 0.003, 0.006, respectively). There was a marked difference in the interaction between self-reported sun exposure and IFN-β in predicting 25(OH)D by level of rs10767935, although this did not reach statistical significance. No SNPs modified the interaction between IFN-β and 25(OH)D in predicting relapse.
Conclusions:We have demonstrated that two-independent SNPs (rs10767935 and rs5030244) in WT1 modified the IFN-β-25(OH)D association in patients with MS. Some evidence was shown for a difference in the sun-IFN-β-25(OH)D association by level of rs10767935. These findings indicate that WT1 variants may play a role in altering the effects of IFN-β on vitamin D in MS.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | interferon-b, genetic, vitamin D, multiple sclerosis |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Central Nervous System |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Lin, R (Ms Lin) |
| Author: | Taylor, BV (Professor Bruce Taylor) |
| Author: | Charlesworth, J (Dr Jac Charlesworth) |
| Author: | van der Mei, I (Associate Professor Ingrid van der Mei) |
| Author: | Blizzard, L (Professor Leigh Blizzard) |
| Author: | Stewart, N (Dr Niall Stewart) |
| Author: | Pittas, F (Dr Fotini Pittas) |
| Author: | Simpson JR, S (Dr Steve Simpson JR) |
| ID Code: | 96155 |
| Year Published: | 2015 (online first 2014) |
| Web of Science® Times Cited: | 9 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2014-10-21 |
| Last Modified: | 2017-11-02 |
| Downloads: | 0 |
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