Zheng, Y and Zhang, D and Zhang, L and Fu, M and Zeng, Y and Russell, R, Variants of NLRP3 gene are associated with insulin resistance in Chinese Han population with type-2 diabetes, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function, 530, (1) pp. 151-154. ISSN 0378-1119 (2013) [Refereed Article]
Copyright 2013 Elsevier
METHODS: Two common variants in NLRP3 gene, rs10754558 and rs4612666, were detected using the polymerase chain reaction-restriction fragment length polymorphism procedure in 952 unrelated T2DM patients and 871 healthy controls. All participants were unrelated Chinese Hans.
RESULTS: The GG genotype and G allele frequencies of rs10754558 were significantly higher in T2DM patients than those in controls (for GG genotype, 19.6% vs. 14.5%, p=0.019; for G allele, 43.9% vs. 39.8%, p=0.013). The GG genotype of rs10754558 was significantly associated with higher LDL-C levels and more prone to insulin resistance, as evaluated by HOMA-IR or QUICK indexes.
CONCLUSIONS: The variant (rs10754558) in NLRP3 is related to insulin resistance and increased risk of T2DM in Chinese Han population.
|Item Type:||Refereed Article|
|Keywords:||Gene polymorphisms; Insulin resistance; NLRP3; Type-2 diabetes|
|Research Division:||Biological Sciences|
|Research Field:||Physiology not elsewhere classified|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|UTAS Author:||Russell, R (Dr Ryan Russell)|
|Web of Science® Times Cited:||22|
|Deposited By:||Menzies Institute for Medical Research|
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