AIMS: Nod like receptor pyrin domain containing 3 (NLRP3) is the best characterized member of nod like receptor family. Recent studies suggest that NLRP3 plays a crucial role in the pathogenesis of type-2 diabetes (T2DM), and variants in NLRP3 affect its mRNA stability and expression. Therefore, we hypothesize that the variants in NLRP3 gene may contribute to T2DM susceptibility. The aim of this study is to evaluate the association of NLRP3 SNPs with T2DM in Chinese Han patients.

METHODS: Two common variants in NLRP3 gene, rs10754558 and rs4612666, were detected using the polymerase chain reaction-restriction fragment length polymorphism procedure in 952 unrelated T2DM patients and 871 healthy controls. All participants were unrelated Chinese Hans.

RESULTS: The GG genotype and G allele frequencies of rs10754558 were significantly higher in T2DM patients than those in controls (for GG genotype, 19.6% vs. 14.5%, p=0.019; for G allele, 43.9% vs. 39.8%, p=0.013). The GG genotype of rs10754558 was significantly associated with higher LDL-C levels and more prone to insulin resistance, as evaluated by HOMA-IR or QUICK indexes.

CONCLUSIONS: The variant (rs10754558) in NLRP3 is related to insulin resistance and increased risk of T2DM in Chinese Han population.

Item Type:	Refereed Article
Keywords:	Gene polymorphisms; Insulin resistance; NLRP3; Type-2 diabetes
Research Division:	Biological Sciences
Research Group:	Zoology
Research Field:	Zoology not elsewhere classified
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Russell, R (Dr Ryan Russell)
ID Code:	96016
Year Published:	2013
Web of Science® Times Cited:	33
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2014-10-15
Last Modified:	2014-11-11
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