Russell, RD and Kraemer, RR and Nelson, AG, Metabolic dysfunction in diabetic offspring: Deviations in metabolic flexibility, Medicine and Science in Sports and Exercise, 45, (1) pp. 8-15. ISSN 0195-9131 (2013) [Refereed Article]
Copyright 2012 by the American College of Sports Medicine
PURPOSE: The purpose of this study was to determine whether a family history of T2D leads to metabolic inflexibility.
METHODS: To examine potential loss of metabolic flexibility at early stages, we used a hooded metabolic cart to compare metabolic characteristics in people with T2D, family history of T2D (FH+), and controls (FH-) 1) at rest, 2) with passive stretching (PS) and recovery, and 3) with oral glucose load. Testing of 9 T2D, 11 FH+, and 9 FH- occurred after a 12-h fast under resting conditions. Expired gas and blood glucose (BG) were measured before and after each condition.
RESULTS: PS lowered BG (P < 0.05) in FH- and FH+ (mean ± SD, -2.7 ± 5.9 and -5.8 ± 7.5 mg·mL(-1)) compared with T2D (-0.9 ± 7.7). CHO use (kcal·min(-1)) increased with PS in all groups (0.04 ± 0.18, 0.03 ± 0.26, and 0.22 ± 1.6 mg·mL(-1) in FH-, FH+, and T2D, respectively). For oral glucose load, different metabolic flexibility existed between FH- as well as FH+ (0.16 ± 0.07) as well as T2D (0.16 ± 0.07), with no difference between FH- and T2D.
CONCLUSION: PS increases glycolytic activity without affecting BG in T2D, and reductions in metabolic flexibility exist in T2D and FH+ without glucoregulatory impairment in FH+, indicating early stage of mitochondrial dysfunction in FH+. Findings indicate PS is an important tool for assessing metabolic flexibility.
|Item Type:||Refereed Article|
|Keywords:||diabetes; diabetic offspring; Metabolic flexibility; metabolism; passive stretching|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Author:||Russell, RD (Dr Ryan Russell)|
|Web of Science® Times Cited:||8|
|Deposited By:||Menzies Institute for Medical Research|
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