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Effects of endurance running and dietary fat on circulating ghrelin and peptide YY

Citation

Russell, RD and Willis, KS and Ravussin, E and Larson-Meyer, ED, Effects of endurance running and dietary fat on circulating ghrelin and peptide YY, Journal of Sports Science and Medicine, 8, (4) pp. 574-583. ISSN 1303-2968 (2009) [Refereed Article]

Copyright Statement

Copyright 2009 Journal of Sports Science and Medicine

Official URL: http://www.jssm.org

Abstract

Ghrelin and peptide YY (PYY) are newly recognized gut peptides involved in appetite regulation. Plasma ghrelin concentrations are elevated in fasting and suppressed following a meal, while PYY concentrations are suppressed in fasting and elevated postprandially. We determine whether ghrelin and PYY are altered by a low-fat, high-carbohydrate (10% fat, 75% carbohydrate) or moderate-fat, moderate-carbohydrate (35% fat, 50% carbohydrate) diet and; whether these peptides are affected by intense endurance running (which is likely to temporarily suppress appetite). Twenty-one endurance-trained runners followed a controlled diet (25% fat) and training regimen for 3 days before consuming the low-fat or isoenergetic moderate-fat diet for another 3 days in random cross-over fashion. On day 7 runners underwent glycogen restoration and then completed a 90-minute pre-loaded 10-km time trial on day 8, following a control breakfast. Blood samples were obtained on days 4 and 7 (fasting), and day 8 (non-fasting) before and after exercise for analysis of ghrelin, PYY, insulin and growth hormone (GH). Insulin, GH, Ghrelin and PYY changed significantly over time (p < 0.0001) but were not influenced by diet. Ghrelin was elevated during fasting (days 4 and 7), while insulin and PYY were suppressed. Following the pre-exercise meal, ghrelin was suppressed ~17% and insulin and PYY were elevated ~157 and ~40%, respectively, relative to fasting (day 7). Following exercise, PYY, ghrelin, and GH were significantly (p < 0.0001) increased by ~11, ~16 and ~813%, respectively. The noted disruption in the typical inverse relationship between ghrelin and PYY following exercise suggests that interaction of these peptides may be at least partially responsible for post-exercise appetite suppression. These peptides do not appear to be influenced by dietary fat intake.

Item Details

Item Type:Refereed Article
Keywords:exercie and gastric hormones
Research Division:Medical and Health Sciences
Research Group:Human Movement and Sports Science
Research Field:Exercise Physiology
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Russell, RD (Dr Ryan Russell)
ID Code:96012
Year Published:2009
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-10-15
Last Modified:2015-03-19
Downloads:0

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