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P-glycoprotein mediated multidrug resistance and its implications for pathology


Trambas, CM and Muller, HK and Woods, GM, P-glycoprotein mediated multidrug resistance and its implications for pathology, Pathology, 29, (2) pp. 122-130. ISSN 0031-3025 (1997) [Refereed Article]

DOI: doi:10.1080/00313029700169734


The discovery of P-glycoprotein has revealed a fundamental mechanism by which cancer cells evade chemotherapy and this principle has proven relevant to general cellular defence mechanisms in normal physiology. To date this knowledge has promised to improve current cancer chemotherapy through the manipulation of drug combinations according to the P-glycoprotein status of the tumor. Furthermore, the discovery of inhibitors of the protein may provide new therapeutic tools in the treatment of multidrug resistant neoplasia, provided the benefits are deemed greater than the potential detrimental side effects. When looking towards future therapies, however, we must also consider additional mechanisms which undoubtedly contribute to clinical drug resistance. Complete elucidation of this complex cellular defence network will hopefully translate into therapeutic opportunities to circumvent all mechanisms of multidrug resistance, thus positively impacting on patient survival.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Trambas, CM (Dr Christina Trambas)
UTAS Author:Muller, HK (Professor Konrad Muller)
UTAS Author:Woods, GM (Professor Gregory Woods)
ID Code:9594
Year Published:1997
Web of Science® Times Cited:17
Deposited By:Pathology
Deposited On:1997-08-01
Last Modified:2011-08-11

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