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Failure of carcinogen-altered dendritic cells to initiate T cell proliferation is associated with reduced IL-1 beta secretion
Citation
Ragg, SJ and Woods, GM and Egan, PJ and Dandie, GW and Muller, HK, Failure of carcinogen-altered dendritic cells to initiate T cell proliferation is associated with reduced IL-1 beta secretion, Cellular Immunology, 178, (1) pp. 17-23. ISSN 0008-8749 (1997) [Refereed Article]
DOI: doi:10.1006/cimm.1997.1110
Abstract
The activation of T cells through presentation of antigen by dendritic cells (DC) relies on many factors, including the correct balance of cytokines in the immediate microenvironment. Antigen presentation by DC migrating from carcinogen-treated skin is impaired as evidenced by the failure of antigen-pulsed DC to initiate specific T cell proliferation. To elucidate mechanism(s) of DC dysfunction, DC migrating from carcinogen-treated skin were collected, pulsed with OVA, and cultured with antigen-specific autologous lymphocytes. Supernatants were assayed for the costimulatory cytokine IL-1β which influences the outcome of DC:T cell interactions. The dendritic cells migrating from carcinogen-treated skin that failed to induce T cell proliferation were unable to produce IL-1β. This may account for the abrogation of DC function following exposure to chemical carcinogens and provides an explanation for the inability of DC to induce a protective immune response to carcinogen-induced tumours.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Cellular immunology |
Objective Division: | Health |
Objective Group: | Other health |
Objective Field: | Other health not elsewhere classified |
UTAS Author: | Ragg, SJ (Dr Scott Ragg) |
UTAS Author: | Woods, GM (Professor Gregory Woods) |
UTAS Author: | Dandie, GW (Dr Geoffrey Dandie) |
UTAS Author: | Muller, HK (Professor Konrad Muller) |
ID Code: | 9593 |
Year Published: | 1997 |
Web of Science® Times Cited: | 7 |
Deposited By: | Pathology |
Deposited On: | 1997-08-01 |
Last Modified: | 2011-08-11 |
Downloads: | 0 |
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