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Failure of carcinogen-altered dendritic cells to initiate T cell proliferation is associated with reduced IL-1 beta secretion

Citation

Ragg, SJ and Woods, GM and Egan, PJ and Dandie, GW and Muller, HK, Failure of carcinogen-altered dendritic cells to initiate T cell proliferation is associated with reduced IL-1 beta secretion, Cellular Immunology, 178, (1) pp. 17-23. ISSN 0008-8749 (1997) [Refereed Article]

DOI: doi:10.1006/cimm.1997.1110

Abstract

The activation of T cells through presentation of antigen by dendritic cells (DC) relies on many factors, including the correct balance of cytokines in the immediate microenvironment. Antigen presentation by DC migrating from carcinogen-treated skin is impaired as evidenced by the failure of antigen-pulsed DC to initiate specific T cell proliferation. To elucidate mechanism(s) of DC dysfunction, DC migrating from carcinogen-treated skin were collected, pulsed with OVA, and cultured with antigen-specific autologous lymphocytes. Supernatants were assayed for the costimulatory cytokine IL-1β which influences the outcome of DC:T cell interactions. The dendritic cells migrating from carcinogen-treated skin that failed to induce T cell proliferation were unable to produce IL-1β. This may account for the abrogation of DC function following exposure to chemical carcinogens and provides an explanation for the inability of DC to induce a protective immune response to carcinogen-induced tumours.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Ragg, SJ (Dr Scott Ragg)
Author:Woods, GM (Professor Gregory Woods)
Author:Dandie, GW (Dr Geoffrey Dandie)
Author:Muller, HK (Professor Konrad Muller)
ID Code:9593
Year Published:1997
Web of Science® Times Cited:7
Deposited By:Pathology
Deposited On:1997-08-01
Last Modified:2011-08-11
Downloads:0

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