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Down-regulation of an established immune response via chemical carcinogen or UVB-altered skin

Citation

Chen, YP and Woods, GM and Dandie, GW and Muller, HK, Down-regulation of an established immune response via chemical carcinogen or UVB-altered skin, Immunology and Cell Biology, 75, (3) pp. 238-244. ISSN 0818-9641 (1997) [Refereed Article]

DOI: doi:10.1038/icb.1997.37

Abstract

The ability to produce antigen-specific down-regulation of an established immune response was investigated in 2,4,6-trinitrochlorobenzene (TNCB)-immune mice by delivery of antigen through chemical carcinogen- or ultraviolet B (UVB)-treated skin. When TNCB-immune mice were treated on the dorsal trunk skin with 7,12-dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen-specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Chen, YP (Mr Yi Peng Chen)
Author:Woods, GM (Professor Gregory Woods)
Author:Dandie, GW (Dr Geoffrey Dandie)
Author:Muller, HK (Professor Konrad Muller)
ID Code:9592
Year Published:1997
Web of Science® Times Cited:3
Deposited By:Pathology
Deposited On:1997-08-01
Last Modified:2011-08-11
Downloads:0

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