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Down-regulation of an established immune response via chemical carcinogen or UVB-altered skin
journal contribution
posted on 2023-05-16, 10:25 authored by Chen, YP, Gregory WoodsGregory Woods, Dandie, GW, Muller, HKThe ability to produce antigen-specific down-regulation of an established immune response was investigated in 2,4,6-trinitrochlorobenzene (TNCB)-immune mice by delivery of antigen through chemical carcinogen- or ultraviolet B (UVB)-treated skin. When TNCB-immune mice were treated on the dorsal trunk skin with 7,12-dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen-specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease.
History
Publication title
Immunology and Cell BiologyVolume
75Pagination
238-244ISSN
0818-9641Department/School
Tasmanian School of MedicinePublisher
Blackwell Publishing AsiaPlace of publication
MelbourneRepository Status
- Restricted