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Down-regulation of an established immune response via chemical carcinogen or UVB-altered skin
Citation
Chen, YP and Woods, GM and Dandie, GW and Muller, HK, Down-regulation of an established immune response via chemical carcinogen or UVB-altered skin, Immunology and Cell Biology, 75, (3) pp. 238-244. ISSN 0818-9641 (1997) [Refereed Article]
Abstract
The ability to produce antigen-specific down-regulation of an established immune response was investigated in 2,4,6-trinitrochlorobenzene (TNCB)-immune mice by delivery of antigen through chemical carcinogen- or ultraviolet B (UVB)-treated skin. When TNCB-immune mice were treated on the dorsal trunk skin with 7,12-dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen-specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Cellular immunology |
Objective Division: | Health |
Objective Group: | Other health |
Objective Field: | Other health not elsewhere classified |
UTAS Author: | Chen, YP (Mr Yi Peng Chen) |
UTAS Author: | Woods, GM (Professor Gregory Woods) |
UTAS Author: | Dandie, GW (Dr Geoffrey Dandie) |
UTAS Author: | Muller, HK (Professor Konrad Muller) |
ID Code: | 9592 |
Year Published: | 1997 |
Web of Science® Times Cited: | 3 |
Deposited By: | Pathology |
Deposited On: | 1997-08-01 |
Last Modified: | 2011-08-11 |
Downloads: | 0 |
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