Zosky, GR and Hart, PH and Whitehouse, AJO and Kusel, MM and Ang, W and Foong, RE and Chen, L and Holt, PG and Sly, PD and Hall, GL, Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age, Annals of the American Thoracic Society, 11, (4) pp. 571-577. ISSN 2325-6621 (2014) [Refereed Article]
Copyright 2014 The American Thoracic Society
Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and postnatal lung function in human populations.
Objectives: To assess the association between maternal vitamin D deficiency, postnatal lung function, and asthmatic status in a longitudinal birth cohort.
Methods: Serum was collected at 16 to 20 weeks' gestation at the time of recruitment in a community-based prospective birth cohort for measurement of vitamin D (25[OH]D). Lung function was assessed by spirometry according to American Thoracic Society guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow-up visits.
Measurements and Main Results: FVC Z-scores in both sexes (β, 0.007 [95% confidence interval (CI), 0.001–0.013]; P = 0.02) and FEV1 Z-scores in girls (β, 0.007 [95% CI, 0.001–0.013]; P = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in boys (odds ratio, 3.03 [95% CI, 1.02–9.02]; P = 0.04).
Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on postnatal lung growth and increase the risk of developing lung disease.
|Item Type:||Refereed Article|
|Keywords:||FEV1, FVC, lung development, 25(OH)D, Raine Study|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Respiratory Diseases|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Respiratory System and Diseases (incl. Asthma)|
|Author:||Zosky, GR (Associate Professor Graeme Zosky)|
|Deposited By:||Medicine (Discipline)|
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