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Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age


Zosky, GR and Hart, PH and Whitehouse, AJO and Kusel, MM and Ang, W and Foong, RE and Chen, L and Holt, PG and Sly, PD and Hall, GL, Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age, Annals of the American Thoracic Society, 11, (4) pp. 571-577. ISSN 2325-6621 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 The American Thoracic Society

DOI: doi:10.1513/AnnalsATS.201312-423OC


Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and postnatal lung function in human populations.

Objectives: To assess the association between maternal vitamin D deficiency, postnatal lung function, and asthmatic status in a longitudinal birth cohort.

Methods: Serum was collected at 16 to 20 weeks' gestation at the time of recruitment in a community-based prospective birth cohort for measurement of vitamin D (25[OH]D). Lung function was assessed by spirometry according to American Thoracic Society guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow-up visits.

Measurements and Main Results: FVC Z-scores in both sexes (β, 0.007 [95% confidence interval (CI), 0.0010.013]; P = 0.02) and FEV1 Z-scores in girls (β, 0.007 [95% CI, 0.0010.013]; P = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in boys (odds ratio, 3.03 [95% CI, 1.029.02]; P = 0.04).

Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on postnatal lung growth and increase the risk of developing lung disease.

Item Details

Item Type:Refereed Article
Keywords:FEV1, FVC, lung development, 25(OH)D, Raine Study
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zosky, GR (Professor Graeme Zosky)
ID Code:95855
Year Published:2014
Deposited By:Medicine
Deposited On:2014-10-09
Last Modified:2018-02-08

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