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KIBRA gene polymorphism has no association with verbal or visual episodic memory performance
Citation
Franks, KH and Summers, MJ and Vickers, JC, KIBRA gene polymorphism has no association with verbal or visual episodic memory performance, Frontiers in Aging Neuroscience, 6 Article 270. ISSN 1663-4365 (2014) [Refereed Article]
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Copyright Statement
Copyright 2014 the authors. Distributed under Creative Commons Attribution ("CC BY") licence.
DOI: doi:10.3389/fnagi.2014.00270
Abstract
Inter-individual variability in memory performance has been suggested to result, in part,
from genetic differences in the coding of proteins involved in long-term potentiation (LTP).
The present study examined the effect of a single-nucleotide polymorphism (SNP) in the
KIBRA gene (rs17070145) on episodic memory performance, using multiple measures
of verbal and visual episodic memory. A total of 256 female and 130 male healthy,
older adults (mean age = 60.86 years) were recruited from the Tasmanian Healthy
Brain Project (THBP), undergoing both neuropsychological and genetic testing. The
current study showed no significant effect of the KIBRA polymorphism on performance
on the Rey Auditory Verbal Learning Task, Logical Memory test, Paired Associates
Learning test or Rey Complex Figure Task. The results suggest there is little to no
functional significance of KIBRA genotype on episodic memory performance, regardless
of modality.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | KIBRA, WWC1, episodic memory, aging, single-nucleotide polymorphism |
| Research Division: | Psychology and Cognitive Sciences |
| Research Group: | Psychology |
| Research Field: | Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Franks, KH (Miss Katherine Franks) |
| Author: | Summers, MJ (Dr Mathew Summers) |
| Author: | Vickers, JC (Professor James Vickers) |
| ID Code: | 95843 |
| Year Published: | 2014 |
| Funding Support: | National Health and Medical Research Council (1003645) |
| Web of Science® Times Cited: | 5 |
| Deposited By: | Psychology |
| Deposited On: | 2014-10-09 |
| Last Modified: | 2017-11-06 |
| Downloads: | 419 View Download Statistics |
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