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Inter-individual variability in memory performance has been suggested to result, in part, from genetic differences in the coding of proteins involved in long-term potentiation (LTP). The present study examined the effect of a single-nucleotide polymorphism (SNP) in the KIBRA gene (rs17070145) on episodic memory performance, using multiple measures of verbal and visual episodic memory. A total of 256 female and 130 male healthy, older adults (mean age = 60.86 years) were recruited from the Tasmanian Healthy Brain Project (THBP), undergoing both neuropsychological and genetic testing. The current study showed no significant effect of the KIBRA polymorphism on performance on the Rey Auditory Verbal Learning Task, Logical Memory test, Paired Associates Learning test or Rey Complex Figure Task. The results suggest there is little to no functional significance of KIBRA genotype on episodic memory performance, regardless of modality.

Item Type:	Refereed Article
Keywords:	KIBRA, WWC1, episodic memory, aging, single-nucleotide polymorphism
Research Division:	Psychology
Research Group:	Biological psychology
Research Field:	Behavioural neuroscience
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Franks, KH (Miss Katherine Franks)
UTAS Author:	Summers, MJ (Dr Mathew Summers)
UTAS Author:	Vickers, JC (Professor James Vickers)
ID Code:	95843
Year Published:	2014
Funding Support:	National Health and Medical Research Council (1003645)
Web of Science® Times Cited:	7
Deposited By:	Psychology
Deposited On:	2014-10-09
Last Modified:	2017-11-06
Downloads:	512 View Download Statistics