eCite Digital Repository

Effect of Hyperglycemia on Cardiac Autonomic Function in Type 2 Diabetes


Tarvainen, MP and Lipponen, JA and Al-Aubaidy, H and Jelinek, HF, Effect of Hyperglycemia on Cardiac Autonomic Function in Type 2 Diabetes, Computing in Cardiology, 9-12 September, 2012, Krakow, Poland, pp. 405-408. ISSN 0276-6574 (2012) [Refereed Conference Paper]


Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation which has been associated with increased risk for cardiac events. In this paper, we examined the associations of blood glucose level (BGL) and duration of diabetes with autonomic nervous system (ANS) function assessed by HRV analysis. Resting HRV and BGL measures of 32 healthy controls and 54 type 2 DM (T2DM) patients were analyzed. HRV data were analyzed using time-domain, frequency-domain and nonlinear methods. HRV parameters showed a clear difference between controls and T2DM patients. BGL correlated negatively with mean RR interval. In addition, a decrease in HRV was observed in hyperglycemia, most clear changes shown in triangular interpolation of RR interval histogram (TINN), root mean square of successive RR interval differences (RMSSD) and PoincarŽe plot index SD1. Duration of diabetes was clearly associated with decreased HRV, shown by decreases in standard deviation of RR intervals (SDNN), HRV triangular index (HRVi), TINN, LF power and PoincarŽe plot index SD2. Glycemic values were not associated with disease duration.

Item Details

Item Type:Refereed Conference Paper
Keywords:Type 2 diabetes mellitus, Hyperglycaemia, Autonomic Nervous System Dysfunction
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, H (Dr Hayder Al-Aubaidy)
ID Code:95791
Year Published:2012
Deposited By:Medicine
Deposited On:2014-10-08
Last Modified:2017-11-01

Repository Staff Only: item control page