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Contrasting signal transduction mechanisms in bacterial and eukaryotic gene transcription

Citation

Cashin, P and Goldsack, L and Hall, D and O'Toole, R, Contrasting signal transduction mechanisms in bacterial and eukaryotic gene transcription, F E M S Microbiology Letters: (Federation of European Microbiological Societies), 261, (2) pp. 155-164. ISSN 0378-1097 (2006) [Substantial Review]

DOI: doi:10.1111/j.1574-6968.2006.00295.x

Abstract

All known cell types use signal transduction systems to respond to an extracellular or intracellular event. The role of these systems can be to adapt to environmental changes or simply to maintain homeostasis. Cells detect and respond to stimuli in a number of ways. Here we review the mechanisms involved in the transmission of a signal from point of detection to site of action. In particular, a comparison is made between the signalling networks which function in gene transcription in bacterial and eukaryotic cells. Knowledge of the similarities between the systems found in the two types of cells can provide a better understanding of the function and origin of signalling components. In addition, the divergence evident can be exploited by molecules that modulate or disrupt the function of differential signalling mechanisms.

Item Details

Item Type:Substantial Review
Keywords:Kinase cascade; Phosphorelay; Transcriptional regulator; Two-component system
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:O'Toole, R (Dr Ronan O'Toole)
ID Code:95780
Year Published:2006
Web of Science® Times Cited:10
Deposited By:Medicine (Discipline)
Deposited On:2014-10-08
Last Modified:2014-10-08
Downloads:0

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