All known cell types use signal transduction systems to respond to an extracellular or intracellular event. The role of these systems can be to adapt to environmental changes or simply to maintain homeostasis. Cells detect and respond to stimuli in a number of ways. Here we review the mechanisms involved in the transmission of a signal from point of detection to site of action. In particular, a comparison is made between the signalling networks which function in gene transcription in bacterial and eukaryotic cells. Knowledge of the similarities between the systems found in the two types of cells can provide a better understanding of the function and origin of signalling components. In addition, the divergence evident can be exploited by molecules that modulate or disrupt the function of differential signalling mechanisms.

Item Type:	Substantial Review
Keywords:	Kinase cascade; Phosphorelay; Transcriptional regulator; Two-component system
Research Division:	Biomedical and Clinical Sciences
Research Group:	Medical microbiology
Research Field:	Medical bacteriology
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	O'Toole, R (Dr Ronan O'Toole)
ID Code:	95780
Year Published:	2006
Web of Science® Times Cited:	15
Deposited By:	Medicine
Deposited On:	2014-10-08
Last Modified:	2014-10-08
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