University of Tasmania
Browse

File(s) not publicly available

Contrasting signal transduction mechanisms in bacterial and eukaryotic gene transcription

journal contribution
posted on 2023-05-22, 23:43 authored by Cashin, P, Goldsack, L, Hall, D, O'Toole, R
All known cell types use signal transduction systems to respond to an extracellular or intracellular event. The role of these systems can be to adapt to environmental changes or simply to maintain homeostasis. Cells detect and respond to stimuli in a number of ways. Here we review the mechanisms involved in the transmission of a signal from point of detection to site of action. In particular, a comparison is made between the signalling networks which function in gene transcription in bacterial and eukaryotic cells. Knowledge of the similarities between the systems found in the two types of cells can provide a better understanding of the function and origin of signalling components. In addition, the divergence evident can be exploited by molecules that modulate or disrupt the function of differential signalling mechanisms.

History

Publication title

F E M S Microbiology Letters: (Federation of European Microbiological Societies)

Volume

261

Pagination

155-164

ISSN

0378-1097

Department/School

Tasmanian School of Medicine

Publisher

Elsevier Science Bv

Place of publication

Po Box 211, Amsterdam, Netherlands, 1000 Ae

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC