Earl, EA and Altaf, M and Murikoli, RV and Swift, S and O'Toole, R, Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis, BMC Alternative Medicine, 10 Article 25. ISSN 1472-6882 (2010) [Refereed Article]
METHODS: Laurelia novae-zelandiae and 44 other native plants were tested for direct anti-bacterial activity. Plants were extracted with different solvents and extracts screened for inhibition of the surrogate species, Mycobacterium smegmatis. Active plant samples were then tested for bacteriostatic activity towards M. tuberculosis and other clinically-important species.
RESULTS: Extracts of six native plants were active against M. smegmatis. Many of these were also inhibitory towards M. tuberculosis including Laurelia novae-zelandiae (Pukatea). M. excelsa (Pohutukawa) was the only plant extract tested that was active against Staphylococcus aureus.
CONCLUSIONS: Our data provide support for the traditional use of Pukatea in treating tuberculosis. In addition, our analyses indicate that other native plant species possess antibiotic activity.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Medical Microbiology|
|Research Field:||Medical Bacteriology|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Infectious Diseases|
|Author:||O'Toole, R (Dr Ronan O'Toole)|
|Web of Science® Times Cited:||5|
|Deposited By:||Medicine (Discipline)|
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