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The association of oxidized high density lipoprotein and oxidized non-high density lipoprotein with the development of microalbuminuria in diabetic nephropathy

journal contribution
posted on 2023-05-18, 04:18 authored by Al-Bayati, MA, Jamil, DA, Al-Aubaidy, HA
This study was undertaken to investigate the association of total lipid peroxides and oxidized HDL in the progression of microalbuminuria in diabetic nephropathy. Fifty-five patients with type 2 diabetes mellitus were recruited in this study and were divided into 2 main groups based on the presence of microalbuminuria, the first group (microalbuminuric group n = 31) had a microalbuminuria between 30-299 ug/mg. The second group (normoalbuminuric group, n = 29) had an albumin level less than 30 ug/mg. The two diabetic groups were compared to the control group (n = 37). The results of our study showed significant elevation in the levels of serum lipid profiles and lipid peroxidation markers in the microalbuminuric group compared to the normoalbuminuric group at P < 0.001. This was associated with significant changes in these markers between the normoalbuminuric group and the control group. In addition, there was also significant changes in the level of these markers in the microalbuminuric group compared to the normoalbuminuric group at P < 0.001. The current study illustrates that the presence of microalbuminuria in type 2 DM can be regarded as an index of increased cardiovascular vulnerability and a signal for vigorous efforts at correction of the known risk factors to avoid the progression of diabetic nephropathy.

History

Publication title

World Journal of Pharmacy and Pharmaceutical Sciences

Issue

7

Pagination

49-59

ISSN

2278-4357

Department/School

Tasmanian School of Medicine

Publisher

World Journal of Pharmacy and Pharmaceutical Sciences

Place of publication

Bulgaria

Rights statement

Copyright 2014 World Journal of Pharmacy and Pharmaceutical Sciences

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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