Al-Aubaidy, HA and Jelinek, HF, Oxidative stress and triglycerides as predictors of subclinical atherosclerosis in prediabetes, Redox Report, 19, (2) pp. 87-91. ISSN 1351-0002 (2014) [Refereed Article]
Copyright 2014 W. S. Maney & Son Ltd
BACKGROUND: The role of triglycerides in early preclinical atherosclerosis is controversial. Antioxidant markers may be associated with triglyceride levels in early preclinical atherosclerosis especially when fasting plasma glucose is raised.
METHODS: This cross-sectional study included 127 participants attending the Diabetes Screening Clinic, Charles Sturt University, Australia.
RESULTS: Serum 8-hydroxy-2-deoxy-guanosine (8-OHdG) was significantly greater in the impaired fasting glucose (IFG) group compared with the control group (536.7 pg/ml ± 249.8 versus 171.4 pg/ml ± 96.9, respectively). The increase in 8-OHdG was associated with a mildly non-significant elevation in low-density lipoprotein level (3.2 ± 1.1 mmol/l) and a poor level of high-density lipoprotein (1.31 ± 0.3 mmol/l) in the IFG group. However, a significant increase in triglycerides (1.6 ± 0.97 mmol/l; P < 0.05) in the IFG group was observed. Erythrocyte reduced glutathione (GSH) levels in the IFG group, although increased, were also not significantly different to control.
CONCLUSION: A significant increase in 8-OHdG is associated with increased levels of triglycerides in the absence of significant changes in reduced GSH and normal levels of cholesterol in the IFG cohort, suggesting that oxidative stress may be present and indicative of subclinical atherosclerosis.
|Item Type:||Refereed Article|
|Keywords:||Subclinical Atherosclerosis, Prediabetes, Oxidative Stress, Serum lipids|
|Research Division:||Medical and Health Sciences|
|Research Group:||Medical Biochemistry and Metabolomics|
|Research Field:||Medical Biochemistry: Carbohydrates|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|UTAS Author:||Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)|
|Web of Science® Times Cited:||22|
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