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Oxidative DNA damage in gestational diabetes melitus: corelation with antioxidants in an Iraqi cohort

Citation

Jamil, D and Al-Aubaidy, H and Smith, L and Jelinek, H, Oxidative DNA damage in gestational diabetes melitus: corelation with antioxidants in an Iraqi cohort, International Journal of Biochemistry Research & Review, 4, (5) pp. 410-419. ISSN 2231-086X (2014) [Refereed Article]


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Copyright Statement

Copyright 2014 Jamil et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.9734/IJBCRR/2014/10138#sthash.ymxLEcDz.dpuf

Abstract

Aims: This study aimed to evaluate the degree of oxidative stress in gestational diabetes mellitus when compared to non-diabetic pregnant women.

Methodology: This cross-sectional study included 73 participants (29 gestational diabetic women and 44 control pregnant women) attending the Maternal and Childhood Unit, Al-Husayniya Medical Centre, Baghdad, Iraq. The data was analyzed using SPSS (Version 14) and Microsoft Excel (Office2007, Microsoft). All values were expressed as mean  standard deviation (MSD).

Results: Serum 8-Hydroxy-2-Deoxyguanosine was significantly (P<.001) greater in the gestational diabetes mellitus group compared to control group (57.217.6 ng/dl versus 19.87.8ng/dl respectively). The increase in 8-Hydroxy-2-Deoxyguanosine was associated with a significant (P<.001) elevation in serum malondialdehyde level (2.10.8 nmol/ml versus 10.4 nmol/ml) and a significant (P=.05) reduction in plasma reduced glutathione in the gestational diabetes mellitus group compared to the control group (20.65 mg/dl compared to 24.14.4 mg/dl). A significant change in total cholesterol (5.41.1mmol/L) and low density lipoprotein cholesterol (3.30.9mmol/L) were also noted in gestational diabetes mellitus group compared to the control group (4.71.3mmol/L and 2.81mmol/L respectively) at P=.05.

Conclusion: An increase in 8-Hydroxy-2-Deoxyguanosine is associated with higher levels of malondialdehyde and a significant reduction in reduced glutathione in gestational diabetes mellitus group, suggesting that significant oxidative stress associated with lipid peroxidation is occurring. Measuring these markers is useful in monitoring gestational diabetes mellitus to prevent the negative outcomes of gestational diabetes mellitus such as increased risk of diabetes and fetal morbidity.

Item Details

Item Type:Refereed Article
Keywords:gestational diabetes, oxidative DNA damage, lipid peroxidation, antioxidants
Research Division:Medical and Health Sciences
Research Group:Medical Biochemistry and Metabolomics
Research Field:Medical Biochemistry: Carbohydrates
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Al-Aubaidy, H (Dr Hayder Al-Aubaidy)
ID Code:95731
Year Published:2014
Deposited By:Medicine (Discipline)
Deposited On:2014-10-08
Last Modified:2015-04-20
Downloads:418 View Download Statistics

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