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Oxidative DNA damage and obesity in type 2 diabetes mellitus


Al-Aubaidy, HA and Jelinek, HF, Oxidative DNA damage and obesity in type 2 diabetes mellitus, European Journal of Endocrinology, 164, (6) pp. 899-904. ISSN 0804-4643 (2011) [Refereed Article]

Copyright Statement

Copyright 2011 European Society of Endocrinology

DOI: doi:10.1530/EJE-11-0053


OBJECTIVE: This study illustrates the relationship between oxidative DNA damage and obesity in patients with prediabetes and type 2 diabetes compared with controls.

DESIGN AND METHODS: Participants attended the School of Community Health, Diabetes Screening Clinic, Charles Sturt University, Australia, between February 2006 and June 2008. A total of 162 participants (35 type 2 diabetic patients; eight prediabetic subjects; and 119 age-, gender-, and weight-matched controls) were investigated. All patients were selected on clinical grounds.

RESULTS: Serum 8-hydroxy 2'-deoxy-guanosine (8-OHdG) level was significantly greater in the prediabetic subjects (671.3140 pg/ml) compared with controls (210.1166 pg/ml; P<0.01). The diabetic group (1979.61209 pg/ml) had the highest level of 8-OHdG. There was a significant increase in serum 8-OHdG in obese subjects (848.5103 pg/ml; P<0.001) and overweight subjects (724102 pg/ml; P=0.005) compared with the lean subjects (196.5327 pg/ml).

CONCLUSION: Our results indicate that serum 8-OHdG is increased already in prediabetes suggesting oxidative DNA damage to be present with minor elevation of blood glucose levels (BGLs). The statistically significant positive correlation between serum 8-OHdG and body mass index in the diabetic group indicates that obesity has an additive effect to increased BGL contributing to oxidative DNA damage.

Item Details

Item Type:Refereed Article
Keywords:Oxidative DNA damage, Obesity, Type 2 diabetes mellitus
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - carbohydrates
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)
ID Code:95728
Year Published:2011
Web of Science® Times Cited:108
Deposited By:Medicine
Deposited On:2014-10-08
Last Modified:2017-11-02

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