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Oxidative DNA damage and obesity in type 2 diabetes mellitus
Citation
Al-Aubaidy, HA and Jelinek, HF, Oxidative DNA damage and obesity in type 2 diabetes mellitus, European Journal of Endocrinology, 164, (6) pp. 899-904. ISSN 0804-4643 (2011) [Refereed Article]
Copyright Statement
Copyright 2011 European Society of Endocrinology
Abstract
OBJECTIVE: This study illustrates the relationship between oxidative DNA damage and obesity in patients with prediabetes and type 2 diabetes compared with controls.
DESIGN AND METHODS: Participants attended the School of Community Health, Diabetes Screening Clinic, Charles Sturt University, Australia, between February 2006 and June 2008. A total of 162 participants (35 type 2 diabetic patients; eight prediabetic subjects; and 119 age-, gender-, and weight-matched controls) were investigated. All patients were selected on clinical grounds.
RESULTS: Serum 8-hydroxy 2'-deoxy-guanosine (8-OHdG) level was significantly greater in the prediabetic subjects (671.3±140 pg/ml) compared with controls (210.1±166 pg/ml; P<0.01). The diabetic group (1979.6±1209 pg/ml) had the highest level of 8-OHdG. There was a significant increase in serum 8-OHdG in obese subjects (848.5±103 pg/ml; P<0.001) and overweight subjects (724±102 pg/ml; P=0.005) compared with the lean subjects (196.5±327 pg/ml).
CONCLUSION: Our results indicate that serum 8-OHdG is increased already in prediabetes suggesting oxidative DNA damage to be present with minor elevation of blood glucose levels (BGLs). The statistically significant positive correlation between serum 8-OHdG and body mass index in the diabetic group indicates that obesity has an additive effect to increased BGL contributing to oxidative DNA damage.
Item Details
Item Type: | Refereed Article |
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Keywords: | Oxidative DNA damage, Obesity, Type 2 diabetes mellitus |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical biochemistry and metabolomics |
Research Field: | Medical biochemistry - carbohydrates |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Al-Aubaidy, HA (Dr Hayder Al-Aubaidy) |
ID Code: | 95728 |
Year Published: | 2011 |
Web of Science® Times Cited: | 108 |
Deposited By: | Medicine |
Deposited On: | 2014-10-08 |
Last Modified: | 2017-11-02 |
Downloads: | 0 |
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