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Improve markers of oxidative stress and coagulation parameters in response to atorvastatin therapy


Mohammad, BI and Hadi, NR and Jawad, HM and Jamil, DA and Al-Aubaidy, HA, Improve markers of oxidative stress and coagulation parameters in response to atorvastatin therapy, British Journal of Pharmaceutical Research, 4, (10) pp. 1242-1252. ISSN 2231-2919 (2014) [Refereed Article]


Copyright Statement

Copyright 2014 Mohammad et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.9734/BJPR/2014/10140#sthash.LsLMD86p.dpuf


Aims: This study was undertaken to investigate the antioxidant effects of atorvastatin in treating cases of atherosclerosis associated with hyperlipidemia.

Methodology: Forty local domestic rabbits were assigned to five groups (eight rabbits in each group): After two weeks acclimatization period, a group of 8 rabbits (Group I) were used as the baseline values of the study parameters. Another 8 rabbits were selected and maintained on standard chow diet (4% fat, 18% protein, 60% carbohydrate, and 4% fibers) throughout the experiment (12 weeks) and served as a normal diet control (Group II). The rest 24 rabbits were fed on an atherogenic diet for 8 weeks to induce atherogenesis. At the end of 8th week, a group of 8 atherogenic rabbits (Group III) were separated and sacrificed and served as an atherogenic-baseline group. The remaining 16 atherogenic rabbits were randomly allocated into two groups; first group received atherogenic diet only for the next four weeks and served as an atherogenic control (Group IV). The other group received atorvastatin (Group V).

Results: Blood samples were collected for serum lipids, coagulation parameters and oxidation parameters. Results showed a significant improvement in the coagulation parameters and oxidation parameters in the atorvastatin treated group compared to the atherogenic control group (P = .01).

Conclusion: This study illustrated the beneficial anti-oxidant effects of atorvastatin in treating atherosclerosis associated with hyperlipidemia.

Item Details

Item Type:Refereed Article
Keywords:atorvastatin, oxidative stress, antioxidants
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Basic pharmacology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)
ID Code:95725
Year Published:2014
Web of Science® Times Cited:1
Deposited By:Medicine
Deposited On:2014-10-08
Last Modified:2015-04-20
Downloads:470 View Download Statistics

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