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Improve markers of oxidative stress and coagulation parameters in response to atorvastatin therapy
Citation
Mohammad, BI and Hadi, NR and Jawad, HM and Jamil, DA and Al-Aubaidy, HA, Improve markers of oxidative stress and coagulation parameters in response to atorvastatin therapy, British Journal of Pharmaceutical Research, 4, (10) pp. 1242-1252. ISSN 2231-2919 (2014) [Refereed Article]
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Copyright Statement
Copyright 2014 Mohammad et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: doi:10.9734/BJPR/2014/10140#sthash.LsLMD86p.dpuf
Abstract
Aims: This study was undertaken to investigate the antioxidant effects of atorvastatin in treating cases of atherosclerosis associated with hyperlipidemia.
Methodology: Forty local domestic rabbits were assigned to five groups (eight rabbits in each group): After two weeks acclimatization period, a group of 8 rabbits (Group I) were used as the baseline values of the study parameters. Another 8 rabbits were selected and maintained on standard chow diet (4% fat, 18% protein, 60% carbohydrate, and 4% fibers) throughout the experiment (12 weeks) and served as a normal diet control (Group II). The rest 24 rabbits were fed on an atherogenic diet for 8 weeks to induce atherogenesis. At the end of 8th week, a group of 8 atherogenic rabbits (Group III) were separated and sacrificed and served as an atherogenic-baseline group. The remaining 16 atherogenic rabbits were randomly allocated into two groups; first group received atherogenic diet only for the next four weeks and served as an atherogenic control (Group IV). The other group received atorvastatin (Group V).
Results: Blood samples were collected for serum lipids, coagulation parameters and oxidation parameters. Results showed a significant improvement in the coagulation parameters and oxidation parameters in the atorvastatin treated group compared to the atherogenic control group (P = .01).
Conclusion: This study illustrated the beneficial anti-oxidant effects of atorvastatin in treating atherosclerosis associated with hyperlipidemia.
Item Details
Item Type: | Refereed Article |
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Keywords: | atorvastatin, oxidative stress, antioxidants |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Pharmacology and pharmaceutical sciences |
Research Field: | Basic pharmacology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Al-Aubaidy, HA (Dr Hayder Al-Aubaidy) |
ID Code: | 95725 |
Year Published: | 2014 |
Deposited By: | Medicine |
Deposited On: | 2014-10-08 |
Last Modified: | 2015-04-20 |
Downloads: | 450 View Download Statistics |
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