Jelinek, HF and Jamil, DA and Al-Aubaidy, HA, Impaired fasting glucose & 8-iso-prostaglandin F₂ₐ in diabetes disease progression, British Journal of Medicine and Medical Research, 4, (33) pp. 5229-5237. ISSN 2231-0614 (2014) [Refereed Article]
Copyright 2014 Jelinek et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Aims: The objective of the present study was to evaluate the changes of 8-isoprostaglandin F2α and other markers of oxidative stress with impaired fasting glucose when compared to non-diabetic control participants.
Methodology: This is a cross-sectional study, conducted at Charles Sturt University, Albury, NSW, Australia and included 428 participants (female: male, 247:181) participants attending the Diabetes Complications Clinic in the School of Community Health for the period between January 2011 to October 2012.
Results: Urinary 8-isoprostaglandin F2α was significantly greater in the impaired fasting glucose group (1.4 ± 1.3 ng/ml) compared to control group (0.68 ± 0.5 ng/ml, P = .05). The increase in urinary 8-isoprostaglandin F2α was associated with a significant elevation in serum total cholesterol (4.7 ± 1.1 mol/L, P = .04) and a significant reduction in high density lipoprotein cholesterol (1.4 ± 0.4 mmol/L, P = .02) in the impaired fasting glucose group compared to the control group. A significant negative correlation was noted between urinary 8-isoprostaglandin F2α and high-density lipoprotein cholesterol among all the participants included in this study (P = .05).
Conclusions: The current study proves the importance of measuring markers of oxidative stress, expressed by urinary 8-isoprostaglandin F2α and serum lipids in managing cases of impaired fasting glucose and suggests a useful biomarker for assessing disease progression and/or remission, especially in the prediabetic state.
|Item Type:||Refereed Article|
|Keywords:||oxidative stress, diabetes mellitus, 8-iso-prostaglandin F2a, impaired fasting glucose, serum lipids|
|Research Division:||Medical and Health Sciences|
|Research Group:||Medical Biochemistry and Metabolomics|
|Research Field:||Medical Biochemistry: Carbohydrates|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|UTAS Author:||Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)|
|Downloads:||382 View Download Statistics|
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