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Impaired fasting glucose & 8-iso-prostaglandin F₂ₐ in diabetes disease progression


Jelinek, HF and Jamil, DA and Al-Aubaidy, HA, Impaired fasting glucose & 8-iso-prostaglandin F₂ₐ in diabetes disease progression, British Journal of Medicine and Medical Research, 4, (33) pp. 5229-5237. ISSN 2231-0614 (2014) [Refereed Article]


Copyright Statement

Copyright 2014 Jelinek et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.9734/BJMMR/2014/11147


Aims: The objective of the present study was to evaluate the changes of 8-isoprostaglandin F and other markers of oxidative stress with impaired fasting glucose when compared to non-diabetic control participants.

Methodology: This is a cross-sectional study, conducted at Charles Sturt University, Albury, NSW, Australia and included 428 participants (female: male, 247:181) participants attending the Diabetes Complications Clinic in the School of Community Health for the period between January 2011 to October 2012.

Results: Urinary 8-isoprostaglandin F was significantly greater in the impaired fasting glucose group (1.4 ± 1.3 ng/ml) compared to control group (0.68 ± 0.5 ng/ml, P = .05). The increase in urinary 8-isoprostaglandin F was associated with a significant elevation in serum total cholesterol (4.7 ± 1.1 mol/L, P = .04) and a significant reduction in high density lipoprotein cholesterol (1.4 ± 0.4 mmol/L, P = .02) in the impaired fasting glucose group compared to the control group. A significant negative correlation was noted between urinary 8-isoprostaglandin F and high-density lipoprotein cholesterol among all the participants included in this study (P = .05).

Conclusions: The current study proves the importance of measuring markers of oxidative stress, expressed by urinary 8-isoprostaglandin F and serum lipids in managing cases of impaired fasting glucose and suggests a useful biomarker for assessing disease progression and/or remission, especially in the prediabetic state.

Item Details

Item Type:Refereed Article
Keywords:oxidative stress, diabetes mellitus, 8-iso-prostaglandin F2a, impaired fasting glucose, serum lipids
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - carbohydrates
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)
ID Code:95722
Year Published:2014
Deposited By:Medicine
Deposited On:2014-10-08
Last Modified:2015-04-20
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