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Evaluating markers of oxidative stress in managing gestational diabetes mellitus: a cross sectional study in Iraq

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Jamil, D and Al-Aubaidy, H and Al-Wasiti, E and Al Bayati, M, Evaluating markers of oxidative stress in managing gestational diabetes mellitus: a cross sectional study in Iraq, British Journal of Medicine and Medical Research, 4, (21) pp. 3870-3877. ISSN 2231-0614 (2014) [Refereed Article]


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Copyright Statement

Copyright 2014 Jamil et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.9734/BJMMR/2014/10139#sthash.nw64U8SZ.dpuf

Abstract

Aims: The objective of the present study was to evaluate the association of oxidative stress markers and antioxidants in gestational diabetes when compared to non-diabetic pregnant women.

Methodology: This is a cross-sectional study, conducted in Al-Husayniya Medical Centre, Baghdad, Iraq and included 73 participants attending the Maternal and Childhood Unit for the period between January 2008 and May 2010.

Results: Serum 8-Hydroxy-2-Deoxyguanosine was significantly greater in the gestational diabetes mellitus group compared to control group (57.2 17.6ng/dl versus 19.8 7.8ng/dl respectively, P < .05). The increase in 8-Hydroxy-2-Deoxyguanosine was associated with a significant elevation in serum total cholesterol and high density lipoprotein cholesterol and a significant reduction in serum superoxide dismutase in the gestational diabetes mellitus group compared to the control group at P < .05. A significant negative correlation was noted between 8-Hydroxy-2-Deoxyguanosine and superoxide dismutase among all the participants included in this study (r = 0.66 at P < .05).

Conclusions: The current study proves the importance of measuring markers of oxidative stress (expressed by serum 8-Hydroxy-2-Deoxyguanosine & serum lipids) and antioxidants (expressed by serum superoxide dismutase) in managing cases of gestational diabetes mellitus and provides a useful way of assessing the disease progression and/or remission in response to the treatment.

Item Details

Item Type:Refereed Article
Keywords:gestational diabetes, oxidative stress, antioxidants, oxidative DNA damage, lipid peroxidation
Research Division:Medical and Health Sciences
Research Group:Medical Biochemistry and Metabolomics
Research Field:Medical Biochemistry: Carbohydrates
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Al-Aubaidy, H (Dr Hayder Al-Aubaidy)
ID Code:95720
Year Published:2014
Deposited By:Medicine (Discipline)
Deposited On:2014-10-08
Last Modified:2015-04-20
Downloads:146 View Download Statistics

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