Jamil, D and Al-Aubaidy, H and Al-Wasiti, E and Al Bayati, M, Evaluating markers of oxidative stress in managing gestational diabetes mellitus: a cross sectional study in Iraq, British Journal of Medicine and Medical Research, 4, (21) pp. 3870-3877. ISSN 2231-0614 (2014) [Refereed Article]
Copyright 2014 Jamil et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Aims: The objective of the present study was to evaluate the association of oxidative stress markers and antioxidants in gestational diabetes when compared to non-diabetic pregnant women.
Methodology: This is a cross-sectional study, conducted in Al-Husayniya Medical Centre, Baghdad, Iraq and included 73 participants attending the Maternal and Childhood Unit for the period between January 2008 and May 2010.
Results: Serum 8-Hydroxy-2-Deoxyguanosine was significantly greater in the gestational diabetes mellitus group compared to control group (57.2 ± 17.6ng/dl versus 19.8 ± 7.8ng/dl respectively, P < .05). The increase in 8-Hydroxy-2-Deoxyguanosine was associated with a significant elevation in serum total cholesterol and high density lipoprotein cholesterol and a significant reduction in serum superoxide dismutase in the gestational diabetes mellitus group compared to the control group at P < .05. A significant negative correlation was noted between 8-Hydroxy-2-Deoxyguanosine and superoxide dismutase among all the participants included in this study (r = 0.66 at P < .05).
Conclusions: The current study proves the importance of measuring markers of oxidative stress (expressed by serum 8-Hydroxy-2-Deoxyguanosine & serum lipids) and antioxidants (expressed by serum superoxide dismutase) in managing cases of gestational diabetes mellitus and provides a useful way of assessing the disease progression and/or remission in response to the treatment.
|Item Type:||Refereed Article|
|Keywords:||gestational diabetes, oxidative stress, antioxidants, oxidative DNA damage, lipid peroxidation|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Medical biochemistry and metabolomics|
|Research Field:||Medical biochemistry - carbohydrates|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Al-Aubaidy, H (Dr Hayder Al-Aubaidy)|
|Downloads:||245 View Download Statistics|
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