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Evaluating markers of oxidative stress in managing gestational diabetes mellitus: a cross sectional study in Iraq


Jamil, D and Al-Aubaidy, H and Al-Wasiti, E and Al Bayati, M, Evaluating markers of oxidative stress in managing gestational diabetes mellitus: a cross sectional study in Iraq, British Journal of Medicine and Medical Research, 4, (21) pp. 3870-3877. ISSN 2231-0614 (2014) [Refereed Article]


Copyright Statement

Copyright 2014 Jamil et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.9734/BJMMR/2014/10139#sthash.nw64U8SZ.dpuf


Aims: The objective of the present study was to evaluate the association of oxidative stress markers and antioxidants in gestational diabetes when compared to non-diabetic pregnant women.

Methodology: This is a cross-sectional study, conducted in Al-Husayniya Medical Centre, Baghdad, Iraq and included 73 participants attending the Maternal and Childhood Unit for the period between January 2008 and May 2010.

Results: Serum 8-Hydroxy-2-Deoxyguanosine was significantly greater in the gestational diabetes mellitus group compared to control group (57.2 17.6ng/dl versus 19.8 7.8ng/dl respectively, P < .05). The increase in 8-Hydroxy-2-Deoxyguanosine was associated with a significant elevation in serum total cholesterol and high density lipoprotein cholesterol and a significant reduction in serum superoxide dismutase in the gestational diabetes mellitus group compared to the control group at P < .05. A significant negative correlation was noted between 8-Hydroxy-2-Deoxyguanosine and superoxide dismutase among all the participants included in this study (r = 0.66 at P < .05).

Conclusions: The current study proves the importance of measuring markers of oxidative stress (expressed by serum 8-Hydroxy-2-Deoxyguanosine & serum lipids) and antioxidants (expressed by serum superoxide dismutase) in managing cases of gestational diabetes mellitus and provides a useful way of assessing the disease progression and/or remission in response to the treatment.

Item Details

Item Type:Refereed Article
Keywords:gestational diabetes, oxidative stress, antioxidants, oxidative DNA damage, lipid peroxidation
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - carbohydrates
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, H (Dr Hayder Al-Aubaidy)
ID Code:95720
Year Published:2014
Deposited By:Medicine
Deposited On:2014-10-08
Last Modified:2015-04-20
Downloads:261 View Download Statistics

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