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Oxidative DNA damage: Antioxidant response in postprandial hyperglycaemia in type 2 diabetes mellitus
Citation
Al-Aubaidy, HA and Jelinek, HF, Oxidative DNA damage: Antioxidant response in postprandial hyperglycaemia in type 2 diabetes mellitus, The British Journal of Diabetes and Vascular Disease, 11, (2) pp. 87-91. ISSN 1474-6514 (2011) [Refereed Article]
Copyright Statement
Copyright 2011 The Authors Sage Publications
DOI: doi:10.1177/1474651411405259
Abstract
The mechanism by which postprandial glucose load and sudden cardiac death are linked is not fully understood. This study compares the postprandial response of 8-hydroxy-deoxy-guanosine (8-OHdG)and erythrocyte glutathione (GSH) in control and type 2 diabetes groups. 8-OHdG was significantly elevated in type 2 diabetic patients (824.1±331.2 and 1087±273.1 pg/ml at the first and second hours respectively, p<0.05, versus 600.4±214.4 pg/ml at baseline) following a glucose load. This was associated with a significant reduction in the level of erythrocyte GSH after the first hour (59.1±9 mg/100ml; p<0.001) compared with the basal level (72.1±9 mg/100ml), followed by a significant elevation in the second hour (71.5±11.1 mg/100ml; p<0.001) compared with the first hour, bringing the GSH level only back to base level. The increase in 8-OHdG in people with type 2 diabetes during the postprandial period further supports previous evidence of a defective antioxidant response and greater risk of heart attack due to blood vessel endothelial cell damage and smooth muscle proliferation.
Item Details
Item Type: | Refereed Article |
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Keywords: | Type 2 diabetes mellitus, oxidative DNA damage, antioxidants |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical biochemistry and metabolomics |
Research Field: | Medical biochemistry - carbohydrates |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Al-Aubaidy, HA (Dr Hayder Al-Aubaidy) |
ID Code: | 95719 |
Year Published: | 2011 |
Deposited By: | Medicine |
Deposited On: | 2014-10-08 |
Last Modified: | 2015-03-18 |
Downloads: | 0 |
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