The mechanism by which postprandial glucose load and sudden cardiac death are linked is not fully understood. This study compares the postprandial response of 8-hydroxy-deoxy-guanosine (8-OHdG)and erythrocyte glutathione (GSH) in control and type 2 diabetes groups. 8-OHdG was significantly elevated in type 2 diabetic patients (824.1±331.2 and 1087±273.1 pg/ml at the first and second hours respectively, p<0.05, versus 600.4±214.4 pg/ml at baseline) following a glucose load. This was associated with a significant reduction in the level of erythrocyte GSH after the first hour (59.1±9 mg/100ml; p<0.001) compared with the basal level (72.1±9 mg/100ml), followed by a significant elevation in the second hour (71.5±11.1 mg/100ml; p<0.001) compared with the first hour, bringing the GSH level only back to base level. The increase in 8-OHdG in people with type 2 diabetes during the postprandial period further supports previous evidence of a defective antioxidant response and greater risk of heart attack due to blood vessel endothelial cell damage and smooth muscle proliferation.

Item Type:	Refereed Article
Keywords:	Type 2 diabetes mellitus, oxidative DNA damage, antioxidants
Research Division:	Biomedical and Clinical Sciences
Research Group:	Medical biochemistry and metabolomics
Research Field:	Medical biochemistry - carbohydrates
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)
ID Code:	95719
Year Published:	2011
Deposited By:	Medicine
Deposited On:	2014-10-08
Last Modified:	2015-03-18
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