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Oxidative DNA damage: Antioxidant response in postprandial hyperglycaemia in type 2 diabetes mellitus

Citation

Al-Aubaidy, HA and Jelinek, HF, Oxidative DNA damage: Antioxidant response in postprandial hyperglycaemia in type 2 diabetes mellitus, The British Journal of Diabetes and Vascular Disease, 11, (2) pp. 87-91. ISSN 1474-6514 (2011) [Refereed Article]

Copyright Statement

Copyright 2011 The Authors Sage Publications

DOI: doi:10.1177/1474651411405259

Abstract

The mechanism by which postprandial glucose load and sudden cardiac death are linked is not fully understood. This study compares the postprandial response of 8-hydroxy-deoxy-guanosine (8-OHdG)and erythrocyte glutathione (GSH) in control and type 2 diabetes groups. 8-OHdG was significantly elevated in type 2 diabetic patients (824.1331.2 and 1087273.1 pg/ml at the first and second hours respectively, p<0.05, versus 600.4214.4 pg/ml at baseline) following a glucose load. This was associated with a significant reduction in the level of erythrocyte GSH after the first hour (59.19 mg/100ml; p<0.001) compared with the basal level (72.19 mg/100ml), followed by a significant elevation in the second hour (71.511.1 mg/100ml; p<0.001) compared with the first hour, bringing the GSH level only back to base level. The increase in 8-OHdG in people with type 2 diabetes during the postprandial period further supports previous evidence of a defective antioxidant response and greater risk of heart attack due to blood vessel endothelial cell damage and smooth muscle proliferation.

Item Details

Item Type:Refereed Article
Keywords:Type 2 diabetes mellitus, oxidative DNA damage, antioxidants
Research Division:Medical and Health Sciences
Research Group:Medical Biochemistry and Metabolomics
Research Field:Medical Biochemistry: Carbohydrates
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)
ID Code:95719
Year Published:2011
Deposited By:Medicine (Discipline)
Deposited On:2014-10-08
Last Modified:2015-03-18
Downloads:0

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