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Aliskiren retards the progression of renal disease in diabetes mellitus: an experimental study in rats


Mohammad, BI and Kareem, ZA and Hadi, NR and Al-Aubaidy, HAM, Aliskiren retards the progression of renal disease in diabetes mellitus: an experimental study in rats, World Journal of Pharmaceutical Research: an international peer review journal for science and pharmacy professional, 2, (6) pp. 1999-2011. ISSN 2277-7105 (2014) [Refereed Article]

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Copyright 2013 World Journal of Pharmaceutical Research

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Objective:This study was undertaken to evaluate the protective effect of aliskiren on renal disease progression in diabetes mellitus. Materials and methods: Twenty-one adult albino rats were randomly divided into 3 groups: the normal control group (NC) injected with citrate buffer,the diabetic control group (DC)injected with streptozotocin (STZ) (60mg/kg I.P), andthe aliskiren treated group (AT),injected with STZ (60mg/kg I.P) and received aliskiren (10 mg/kg orally daily for 8 weeks). At the end of 8th weeks, blood& urine samples were collected for measurements of random blood sugar (RBS), HbA1c, renal function parameters,malondialdehyde (MDA) and reduced glutathione (GSH). Monocyte chemoattractant protein-1 (MCP-1) and histopathological assessment of degree of renal damage also performed.

Results: Compared to DC group, there is a significant decrease in the levels of blood urea (40.12.31), uric acid (4.130.191), serum creatinine (0.890.074), albuminuria (27.42.03), andMDA(1.210.013) in the ATgroup,(p≤0.05). Expression of renal MCP-1 significantly decreased associated with a significant reduction in glomerular lesion in AT group compared to NC group (p<0.001).

Conclusion: We concluded that aliskiren is helpful in reducing lipid peroxidation, improvingrenal function and reducingrenal expression of inflammatory markers and consequently reduces the progression of diabetic nephropathy.

Item Details

Item Type:Refereed Article
Keywords:aliskiren, diabetes mellitus, diabetic nephropathy
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biochemistry and metabolomics
Research Field:Medical biochemistry - carbohydrates
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Al-Aubaidy, HAM (Dr Hayder Al-Aubaidy)
ID Code:95714
Year Published:2014
Deposited By:Medicine
Deposited On:2014-10-08
Last Modified:2015-01-13

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