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Experimental Models Used to Study Human Tuberculosis


O'Toole, RF, Experimental Models Used to Study Human Tuberculosis, Advances in Applied Microbiology, Elsevier, Allen I. Laskin; Sima Sariaslani; Geoffrey M. Gadd (ed), United States, pp. 76-84. ISBN 978-0-12-380993-3 (2010) [Research Book Chapter]

DOI: doi:10.1016/S0065-2164(10)71003-0


Mycobacterium tuberculosis causes more deaths in humans than any other bacterial pathogen. The most recent data from the World Health Organization reveal that over 9 million new cases of tuberculosis occur each year and that the incidence appears to be increasing with population growth. Despite the global burden of tuberculosis, we are still reliant on relatively dated measures to prevent, diagnose, and treat the disease. New, more effective tools are needed to diminish the incidence of tuberculosis. M. tuberculosis lacks a natural host beyond humans and, hence, surrogate models have been employed in the study of the pathogen. The discovery and development of new vaccines, diagnostics, or antitubercular drugs are dependent upon the validity of any experimental model used and its relevance to tuberculosis in humans. In this review, a range of experimental models, from in vitro studies with fast-growing low-pathogenic species of mycobacteria to the infection of nonhuman primates with virulent M. tuberculosis, will be discussed.

Item Details

Item Type:Research Book Chapter
Research Division:Biomedical and Clinical Sciences
Research Group:Medical microbiology
Research Field:Medical bacteriology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:O'Toole, RF (Dr Ronan O'Toole)
ID Code:95706
Year Published:2010
Web of Science® Times Cited:20
Deposited By:Medicine
Deposited On:2014-10-07
Last Modified:2014-10-07

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