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Identification and bioactivity of 3-epi-xestoaminol C isolated from the New Zealand brown alga Xiphophora chondrophylla
journal contribution
posted on 2023-05-18, 04:13 authored by Dasyam, N, Munkacsi, AB, Fadzilah, NH, Senanayake, DS, O'Toole, RF, Keyzers, RAWe report here the bioassay-guided isolation of a new 1-deoxysphingoid, 3-epi-xestoaminol C (1), isolated from the New Zealand brown alga Xiphophora chondrophylla. This is the first report of a 1-deoxysphingoid from a brown alga. We describe the isolation and full structure elucidation of this compound, including its absolute configuration, along with its bioactivity against mycobacteria and mammalian cell lines and preliminary mechanism of action studies using yeast chemical genomics.
History
Publication title
Journal of Natural ProductsVolume
77Issue
6Pagination
1519-23ISSN
0163-3864Department/School
Tasmanian School of MedicinePublisher
Amer Chemical SocPlace of publication
1155 16Th St, Nw, Washington, USA, Dc, 20036Rights statement
Copyright 2014 American Chemical Society and American Society of PharmacognosyRepository Status
- Restricted