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Identification and bioactivity of 3-epi-xestoaminol C isolated from the New Zealand brown alga Xiphophora chondrophylla

Citation

Dasyam, N and Munkacsi, AB and Fadzilah, NH and Senanayake, DS and O'Toole, RF and Keyzers, RA, Identification and bioactivity of 3-epi-xestoaminol C isolated from the New Zealand brown alga Xiphophora chondrophylla, Journal of Natural Products, 77, (6) pp. 1519-23. ISSN 0163-3864 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 American Chemical Society and American Society of Pharmacognosy

DOI: doi:10.1021/np500171z

Abstract

We report here the bioassay-guided isolation of a new 1-deoxysphingoid, 3-epi-xestoaminol C (1), isolated from the New Zealand brown alga Xiphophora chondrophylla. This is the first report of a 1-deoxysphingoid from a brown alga. We describe the isolation and full structure elucidation of this compound, including its absolute configuration, along with its bioactivity against mycobacteria and mammalian cell lines and preliminary mechanism of action studies using yeast chemical genomics.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:O'Toole, RF (Dr Ronan O'Toole)
ID Code:95681
Year Published:2014
Web of Science® Times Cited:9
Deposited By:Medicine (Discipline)
Deposited On:2014-10-07
Last Modified:2017-11-03
Downloads:0

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