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Identification and bioactivity of 3-epi-xestoaminol C isolated from the New Zealand brown alga Xiphophora chondrophylla

journal contribution
posted on 2023-05-18, 04:13 authored by Dasyam, N, Munkacsi, AB, Fadzilah, NH, Senanayake, DS, O'Toole, RF, Keyzers, RA
We report here the bioassay-guided isolation of a new 1-deoxysphingoid, 3-epi-xestoaminol C (1), isolated from the New Zealand brown alga Xiphophora chondrophylla. This is the first report of a 1-deoxysphingoid from a brown alga. We describe the isolation and full structure elucidation of this compound, including its absolute configuration, along with its bioactivity against mycobacteria and mammalian cell lines and preliminary mechanism of action studies using yeast chemical genomics.

History

Publication title

Journal of Natural Products

Volume

77

Issue

6

Pagination

1519-23

ISSN

0163-3864

Department/School

Tasmanian School of Medicine

Publisher

Amer Chemical Soc

Place of publication

1155 16Th St, Nw, Washington, USA, Dc, 20036

Rights statement

Copyright 2014 American Chemical Society and American Society of Pharmacognosy

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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