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What is the appropriate age cut-off for cycloplegia in refraction?


Sanfilippo, PG and Chu, B-S and Bigault, O and Kearns, LS and Boon, M-Y and Young, TL and Hammond, CJ and Hewitt, AW and Mackey, DA, What is the appropriate age cut-off for cycloplegia in refraction?, Acta Ophthalmologica, 92, (6) pp. e458-e462. ISSN 1755-375X (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Acta Ophthalmologica Scandinavica Foundation

DOI: doi:10.1111/aos.12388


Purpose: To investigate the age range for which cycloplegia provides additional information compared with non-cycloplegic refraction in teenagers and young adults.

Methods: Data for 1295 subjects (704 female; 591 male) from the Twins Eye Study in Tasmania (TEST) and the Brisbane Adolescent Twin Study (mean age: 19.65 3.56, range: 13-26 years) were included. For all participants, cycloplegia was induced by instillation of either one drop of 1% cyclopentolate (13-14 years) or one drop of 1% tropicamide (15-26 years). Pre- and postcycloplegic refractive errors for both eyes were measured using a Humphrey-598 automated refractor and spherical equivalents of refractive error were calculated. Generalized Estimating Equations (GEE) were used to model the spherical equivalent refraction (SER) for each eye against age (by year) and axial length (in the given eye).

Results: The mean group difference between pre- and postcycloplegic SER (post minus pre) was 0.17 0.52 D and 0.12 0.51 D for the right and left eyes, respectively, indicating that postcycloplegic refraction was generally more hyperopic/less myopic. The mean difference between pre- and postcycloplegic SER decreased from 0.36 0.41 D in the 13-year-olds to 0.06 0.50 D in people aged 25 years. After adjusting for family-relatedness, the difference between pre- and postcycloplegia SER was significant in all age groups up until the age of 20 years.

Conclusions: Non-cycloplegic autorefraction can result in group mean SER differences of greater myopia than cycloplegic autorefraction and occurs in teenagers (13-19 years of age), but not in adults 20-26 years. These data suggest that cycloplegia is not required in population estimates of refractive error for young adults once they reach approximately 20 years of age.

Item Details

Item Type:Refereed Article
Keywords:accommodation, autorefraction, cycloplegia, generalized estimating equations, spherical equivalent
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
UTAS Author:Mackey, DA (Professor David Mackey)
ID Code:95494
Year Published:2014
Web of Science® Times Cited:44
Deposited By:Medicine
Deposited On:2014-10-02
Last Modified:2017-11-07

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