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Epigenetic effects on eye diseases


Hewitt, AW and Wang, JJ and Liang, H and Craig, JE, Epigenetic effects on eye diseases, Expert Review of Ophthalmology, 7, (2) pp. 127-134. ISSN 1746-9899 (2012) [Refereed Article]

DOI: doi:10.1586/eop.12.11


Epigenetics is the process by which patterns of gene expression are modified in a mitotically heritable manner. However, these epigenetic variations are not attributable to changes in the primary nucleotide sequence within DNA. In this review, the emerging field of epigenetics is introduced and the potential role it may have in the manifestation of common ocular disease is explored. Given our current understanding of the genetic, environmental and phenotypic profiles, it is probable that stochastic epigenetic effects have an important role in the pathogenesis of age-related macular degeneration, glaucoma, cataract and myopia. The ability to profile individuals at an epigenetic level offers a novel means to intimately dissect gene-environment interactions.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
ID Code:95410
Year Published:2012
Deposited By:Medicine
Deposited On:2014-10-01
Last Modified:2014-10-01

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