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Quantitative genetic analysis of the retinal vascular caliber: The australian twins eye study

Citation

Sun, C and Zhu, G and Wong, TY and Hewitt, A and Ruddle, JB and Hodgson, L and Montgomery, GW and Young, TL and Hammond, CJ and Craig, JE and Martin, NG and He, M and Mackey, DA, Quantitative genetic analysis of the retinal vascular caliber: The australian twins eye study, Hypertension, 54, (4) pp. 788-795. ISSN 0194-911X (2009) [Refereed Article]

DOI: doi:10.1161/HYPERTENSIONAHA.109.132902

Abstract

Research into the genetic effects and specific genes associated with retinal vascular caliber, a risk marker of cardiovascular diseases, may provide new insights into the genetic contribution of early microvascular disease. A combined 374 monozygotic and 536 dizygotic twin pairs and 322 siblings from the Twins Eye Study in Tasmania and the Brisbane Adolescent Twin Study underwent complete ophthalmic examinations, including retinal photography, and bilateral retinal vascular caliber was measured. Structural equation modeling was used to estimate the heritability. Genome-wide linkage analysis was conducted on 836 individuals from 381 Brisbane Adolescent Twin Study families, with adjustments for age, sex, and other covariates. The heritabilities for the retinal arteriolar caliber were 59.4% (95% CI: 53.2% to 64.7%) and 56.5% (95% CI: 50.1% to 61.9%) in the Twins Eye Study in Tasmania and the Brisbane Adolescent Twin Study, respectively, and for venular caliber they were 61.7% (95% CI: 55.6% to 67.0%) and 64.2% (95% CI: 58.7% to 68.8%), respectively, after adjusting for age, sex, and body mass index. Two multipoint peaks detected on chromosomes 3p12.3 and 8p23.1 for retinal arteriolar caliber had suggestive linkage, with the highest multipoint peak logarithm of odds score of 2.24 on chromosome 8p23.1 (genome-wide P=7.010-4). Two suggestive logarithm of odds scores for venular caliber were identified on chromosomes 2p14 and 9q21.13. The largest multipoint logarithm of odds score was 2.69 on chromosome 2p14 (genome-wide P=2.010-4). In this large twin population, genetic factors appear to play a significant role in the variation of retinal vascular caliber. Several putative loci were identified for the retinal vascular caliber.

Item Details

Item Type:Refereed Article
Keywords:Genetics; Genome-wide linkage analysis; Heritability; Retinal vascular caliber; Twins
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Hewitt, A (Dr Alex Hewitt)
Author:Mackey, DA (Professor David Mackey)
ID Code:95279
Year Published:2009
Web of Science® Times Cited:21
Deposited By:Medicine (Discipline)
Deposited On:2014-09-29
Last Modified:2014-09-29
Downloads:0

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