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Twins Eye Study in Tasmania (TEST): Rationale and methodology to recruit and examine twins
journal contribution
posted on 2023-05-18, 03:50 authored by David MackeyDavid Mackey, Mackinnon, JR, Brown, SA, Kearns, LS, Ruddle, JB, Sanfilippo, PG, Sun, C, Hammond, CJ, Young, TL, Martin, NG, Alexander HewittAlexander HewittVisual impairment is a leading cause of morbidity and poor quality of life in our community. Unravelling the mechanisms underpinning important blinding diseases could allow preventative or curative steps to be implemented. Twin siblings provide a unique opportunity in biology to discover genes associated with numerous eye diseases and ocular biometry. Twins are particularly useful for quantitative trait analysis through genome-wide association and linkage studies. Although many studies involving twins rely on twin registries, we present our approach to the Twins Eye Study in Tasmania to provide insight into possible recruitment strategies, expected participation rates and potential examination strategies that can be considered by other researchers for similar studies. Five separate avenues for cohort recruitment were adopted: (1) piggy-backing existing studies where twins had been recruited, (2) utilizing the national twin registry, (3) word-of-mouth and local media publicity, (4) directly approaching schools, and finally (5) collaborating with other research groups studying twins.
History
Publication title
Twin Research and Human GeneticsVolume
12Issue
5Pagination
441-454ISSN
1832-4274Department/School
Tasmanian School of MedicinePublisher
Cambridge University PressPlace of publication
United KingdomRepository Status
- Restricted