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Relationship between pulmonary artery volumes at computed tomography and pulmonary artery pressures in patients with- and without pulmonary hypertension
Citation
Froelich, JJ and Koenig, H and Knaak, L and Krass, S and Klose, KJ, Relationship between pulmonary artery volumes at computed tomography and pulmonary artery pressures in patients with- and without pulmonary hypertension, European Journal of Radiology, 67, (3) pp. 466-471. ISSN 0720-048X (2008) [Refereed Article]
DOI: doi:10.1016/j.ejrad.2007.08.022
Abstract
Objectives: This study was designed to determine the relationship between pulmonary artery (PA) volumes at computed tomography (CT) and PA pressures at right-sided heart catheterization in patients with and without pulmonary hypertension (PAH) to develop a noninvasive CT method of PA pressure quantification.
Materials and methods: Sixteen patients with chronic sleep apnea syndrome underwent contrast enhanced helical CT (slice thickness 3 mm; pitch 2; increment 2 mm) at inspiration. Eight patients had PAH while cardiopulmonary disease has been excluded in eight other patients. Vascular volumes were determined using a 3D technique (threshold seeded vascular tracing algorithm; thresholds -600 H [lower] and 3000 H [upper]). Right-sided heart catheterization measurements were available for linear regression analysis of PA volumes and pressures.
Results: Correlation between PA pressures and volumes (normalized for BMI), was high in both groups (without PAH: r = .85; with PAH .90, Pearson). Compared to elevated PA pressures in patients with pulmonary hypertension (p < .005), PA volumes also were significantly increased (p < .05) among the groups. Conclusions: High correlation was found between PA volumes and mean PA pressures in patients with- and without PAH. Significant differences in PA volumes at CT-volumetry may admit non-invasive determination of pulmonary hypertension.
Item Details
Item Type: | Refereed Article |
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Keywords: | Computed tomography (CT); Hypertension; Lung; Lung diseases; Pulmonary; Pulmonary arteries |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Froelich, JJ (Professor Jens Froelich) |
ID Code: | 95247 |
Year Published: | 2008 |
Web of Science® Times Cited: | 18 |
Deposited By: | Medicine |
Deposited On: | 2014-09-29 |
Last Modified: | 2014-09-29 |
Downloads: | 0 |
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