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Associations of birth weight with ocular biometry, refraction, and glaucomatous endophenotypes: The australian twins eye study

Citation

Sun, C and Ponsonby, AL and Brown, Shayne and Kearns, LS and MacKinnon, JR and Barbour, JM and Ruddle, JB and Hewitt, A and Wright, MJ and Martin, NG and Dwyer, T and Mackey, DA, Associations of birth weight with ocular biometry, refraction, and glaucomatous endophenotypes: The australian twins eye study, American Journal of Ophthalmology, 150, (6) pp. 909-916. ISSN 0002-9394 (2010) [Refereed Article]

DOI: doi:10.1016/j.ajo.2010.06.028

Abstract

Purpose: To examine the relationship of birth weight with ocular measures in a Caucasian twin population. Design Cross-sectional study of 1498 twins (308 monozygotic and 441 dizygotic pairs) aged between 5 to 80 years participating in the Australian Twins Eye Study. Methods All participants underwent ophthalmic examination including bilateral cycloplegic autorefraction, keratometry, interpupillary distance (IPD), central corneal thickness, intraocular pressure (IOP), and retinal photography. Birth weight and gestation were obtained from a self-administered questionnaire. A subset of the twins also participated in the Tasmanian Infant Health Study (288) and the Childhood Blood Pressure Study (184), which collected data on birth parameters allowing for verification of data. Linear mixed models were used for the main analysis. Results Both the within-pair (βw 0.27, 95% confidence interval [CI] 0.15, 0.38 mm per kg increase in birth weight, P < .001) and between-pair associations (βB 0.22, 95% CI 0.08, 0.35, P = .002) of birth weight with axial length were significant and of similar magnitude (difference in effect, P = .56), after adjusting for relevant confounders. In contrast, birth weight was negatively associated with corneal curvature (βw -0.82, 95% CI -1.09, -0.55 diopters per kg increase; βB -0.69, 95% CI -0.98, -0.41, both P < .001). These associations remained significant within dizygotic and monozygotic pairs. Refraction, anterior chamber depth, IPD, IOP, and optic disc parameters are unrelated to birth weight. Conclusions Consistent with previous studies in singleton children, lower birth weight is associated with shorter axial length and more curved corneas in this twin study. This also adds new insights into the emmetropization process.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Ponsonby, AL (Professor Anne Ponsonby)
Author:Brown, Shayne (Ms Shayne Brown)
Author:Hewitt, A (Dr Alex Hewitt)
Author:Dwyer, T (Professor Terry Dwyer)
Author:Mackey, DA (Professor David Mackey)
ID Code:95101
Year Published:2010
Web of Science® Times Cited:6
Deposited By:Medicine (Discipline)
Deposited On:2014-09-24
Last Modified:2014-09-24
Downloads:0

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