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Rationale, methods and baseline demographics of the Bhaktapur Glaucoma Study


Thapa, SS and Rana, PP and Twayana, SN and Shrestha, MK and Paudel, I and Paudyal, G and Gurung, R and Ruit, S and Hewitt, A and Craig, JE and van Rens, G, Rationale, methods and baseline demographics of the Bhaktapur Glaucoma Study, Clinical and Experimental Ophthalmology, 39, (2) pp. 126-134. ISSN 1442-6404 (2011) [Refereed Article]

DOI: doi:10.1111/j.1442-9071.2010.02429.x


Background: To describe the methodology and baseline data of a population-based study designed to determine the prevalence of glaucoma and to study the risk factors for glaucoma development in a Nepali population. Design: Population-based cross-sectional study Participants: Subjects 40years and above residing in Bhaktapur District. Patients and Methods: Power calculations suggest that a sample size of 4758 is required. Thirty clusters were randomly selected from the 2 municipalities and 16 Village Development Committees of Bhaktapur District in Nepal. A door-to-door census was conducted in the selected clusters to identify citizens 40years of age and older. Demographic details were collected and a structured interview, regarding awareness for cataract and glaucoma was taken. All individuals fulfilling the eligibility criteria were recruited and referred to the Tilganga Institute of Ophthalmology in Kathmandu for a detailed clinical examination including glaucoma diagnostic procedures. Peripheral blood samples were taken to facilitate future genetic analysis. Main Outcome Measures: Prevalence of glaucoma, risk factors and genetic screening. Results: A total of 4800 people were selected. The mean age of participants was 55.412.3years (range: 40-99) and 51.8% were female. In total, 64.8% of our cohort was aged less than 59years and 60.5% were illiterate. Among the various ethnic races, 69.7% belonged to the Newar ethnic group. Conclusion: This study will determine the prevalence of glaucoma and allow for an increased understanding of the risk factors for glaucoma development in this region. 2010 The Authors. Clinical and Experimental Ophthalmology 2010 Royal Australian and New Zealand College of Ophthalmologists.

Item Details

Item Type:Refereed Article
Keywords:Epidemiology; Genetics; Glaucoma; Nepal; Population-based studies; Prevalence
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hewitt, A (Professor Alex Hewitt)
ID Code:95100
Year Published:2011
Web of Science® Times Cited:15
Deposited By:Medicine
Deposited On:2014-09-24
Last Modified:2017-11-07

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