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Four novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo


Ikram, MK and Xueling, S and Jensen, RA and Cotch, MF and Hewitt, AW and Ikram, MA and Wang, JJ and Klein, R and Klein, BEK and Breteler, MMB and Cheung, N and Liew, G and Mitchell, R and Uitterlinden, AG and Rivadeneira, F and Hofman, A and de Jong, PTVM and van Duijn, CM and Kao, L and Cheng, C and Smith, AV and Glazer, NL and Lumley, T and McKnight, B and Psaty, BM and Jonasson, F and Eiriksdottir, G and Aspelund, T and Harris, TB and Launer, LJ and Taylor, KD and Bis, JC and Wiggins, K and Heckbert, SR and Hammond, CJ and Andrew, T and Fahy, A and Attia, J and Holliday, EG and Scott, RJ and Islam, FMA and Rotter, JI and McAuley, A and Boerwinkle, E and Tai, ES and Gudnason, V and Siscovick, DS and Vingerling, JR and Wong, TY, Global BPgen Consortium, Four novel loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo, PL o S Genetics, 6, (10) pp. 1-12. ISSN 1553-7390 (2010) [Refereed Article]


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Licenced under Creative Commons Attribution 3.0 Unported (CC BY 3.0)

DOI: doi:10.1371/journal.pgen.1001184


There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n = 6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p<5.010-8) with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p = 1.6110-25, within the RASIP1 locus), rs225717 (6q24; p = 1.2510-16, adjacent to the VTA1 and NMBR loci), rs10774625 (12q24; p = 2.1510-13, in the region of ATXN2,SH2B3 and PTPN11 loci), and rs17421627 (5q14; p = 7.3210-16, adjacent to the MEF2C locus). In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
ID Code:95096
Year Published:2010
Web of Science® Times Cited:99
Deposited By:Medicine
Deposited On:2014-09-24
Last Modified:2014-10-09
Downloads:312 View Download Statistics

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