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Raine eye health study: Design, methodology and baseline prevalence of ophthalmic disease in a birth-cohort study of young adults


Yazar, S and Forward, H and Mcknight, CM and Tan, A and Soloshenko, A and Oates, SK and Ang, W and Sherwin, JC and Wood, D and Mountain, JA and Pennell, CE and Hewitt, AW and Mackey, DA, Raine eye health study: Design, methodology and baseline prevalence of ophthalmic disease in a birth-cohort study of young adults, Ophthalmic Genetics, 34, (4) pp. 199-208. ISSN 1381-6810 (2013) [Refereed Article]

DOI: doi:10.3109/13816810.2012.755632


PURPOSE: The Raine Eye Health Study (REHS) was conceived to determine the prevalence of and risk factors for eye disease in young adults, and to characterize ocular biometric parameters in a young adult cohort. This article summarizes the rationale and study design of REHS and outlines the baseline prevalence of ophthalmic disease in this population.

METHODS: The Western Australian Pregnancy Cohort (Raine) Study originated as a randomized-controlled trial of 2900 women recruited from the state's largest maternity hospital. Their offspring (N = 2868) have been followed at birth, ages 1, 2, 3, 5, 8, 10, 14, 17 and 20 years of age in a prospective cohort study. DNA has been collected from participants for genome-wide association studies. At the 20-year follow-up participants completed a comprehensive eye assessment that included visual acuity, orthoptic assessment and cycloplegic autorefraction, as well as several ocular biometric variables and multiple ophthalmic photographs of the anterior and posterior segments.

RESULTS: A total of 1344 participants (51.3% male) were assessed over a 24-month period. For the majority of examined participants (85.5%) both parents were Caucasian, 63.3% had completed school year 12 or equivalent, 5.5% had myopia (spherical equivalent ≤-3 diopters) and 15 participants (1.2%) had unilateral or bilateral pterygia. Keratoconus, cataract, keratitis and uveitis were rare.

CONCLUSION: The REHS design and methodology allow comparison with other population-based studies of eye disease. The study established the prevalence of eye disorders in a large sample of predominantly Caucasian young Australian adults.

Item Details

Item Type:Refereed Article
Keywords:Birth cohort study; Epidemiology; Participation; Raine Study; Recruitment; Young adults
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hewitt, AW (Professor Alex Hewitt)
UTAS Author:Mackey, DA (Professor David Mackey)
ID Code:95079
Year Published:2013
Web of Science® Times Cited:34
Deposited By:Medicine
Deposited On:2014-09-24
Last Modified:2014-09-24

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