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Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis


Bolos, M and Hu, Y and Young, KM and Foa, L and Small, DH, Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis, Journal of Biological Chemistry, 289, (45) pp. 31253-31261. ISSN 0021-9258 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 the American Society for Biochemistry and Molecular Biology

DOI: doi:10.1074/jbc.M114.581918


Amyloid-β precursor protein (APP) is well studied for its role in Alzheimers disease, although its normal function remains uncertain. It has been reported that APP stimulates the proliferation and neuronal differentiation of neural stem / progenitor cells (NSPCs). In this study, we examined the role of APP in NSPC differentiation. To identify proteins that may mediate the effect of APP on NSPC differentiation, we used a gene array approach to find genes whose expression correlated with APP-induced neurogenesis. We found that the expression of neurogenin 2 (Ngn2), a basic helix-loop-helix transcription factor, was significantly downregulated in NSPCs from APP knockout mice (APPKO) and increased in APP transgenic (Tg2576) mice. Ngn2 overexpression in APPKO NSPCs promoted neuronal differentiation, whereas siRNA knockdown of Ngn2 expression in wild-type (WT) NSPCs decreased neuronal differentiation. The results demonstrate that APP-stimulated neuronal differentiation of NSPCs is mediated by Ngn2.

Item Details

Item Type:Refereed Article
Keywords:Neural stem cells
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Bolos, M (Dr Marta Bolos Jurado)
UTAS Author:Hu, Y (Mr Yifei Hu)
UTAS Author:Young, KM (Associate Professor Kaylene Young)
UTAS Author:Foa, L (Professor Lisa Foa)
UTAS Author:Small, DH (Professor David Small)
ID Code:94838
Year Published:2014
Funding Support:National Health and Medical Research Council (1045240)
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2014-09-18
Last Modified:2017-11-06

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