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Successful treatment of negative pressure hydrocephalus using timely titrated external ventricular drainage: a case series

Citation

Hunn, BHM and Mujic, A and Sher, I and Dubey, AK and Peters-Willke, J and Hunn, AWM, Successful treatment of negative pressure hydrocephalus using timely titrated external ventricular drainage: a case series, Clinical Neurology and Neurosurgery: An International Journal Publishing Papers and Reports on The Clinical Aspects of Neurology and Neurosurgery, 116 pp. 67-71. ISSN 0303-8467 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.clineuro.2013.10.019

Abstract

Objective: Negative-pressure hydrocephalus (NegPH) is a rare clinical entity characterised by enlarged ventricles and symptoms consistent with increased intracranial pressure (ICP) in the setting of negative ICP. Little has been published regarding appropriate treatment and outcomes of negative-pressure hydrocephalus patients, and no data have been published demonstrating successful therapy producing acceptable long-term outcomes. Here we present 8 cases successfully treated by titrated external ventricular drainage (TEVD), including drainage at negative (subatmospheric) pressure, and subsequent low-pressure ventriculoperitoneal shunting.

Methods: A retrospective audit of all cases of negative-pressure hydrocephalus occurring at a university teaching hospital between 2006 and 2012 was undertaken. The clinical features of these cases, results of radiological investigations, treatment, and outcome were drawn from the patients' records.

Results: Eight cases of NegPH were identified. All patients had at least one preceding intracranial procedure (mean number of procedures 3.0). All cases were treated using TEVD, titrated to produce between 5 and 15 mL per hour of CSF drainage, including drainage under subatmospheric pressure if this was required to maintain CSF flow. Mean delay from first negative ICP to TEVD was 1.8 days. All 8 patients demonstrated clinical improvement. TEVD resulted in improvement in Glasgow Coma Scale (mean increase 4.6, p = 0.003), and increases in ICP (mean increase 8.5, p < 0.001). Mean length of follow-up was 471.8 days. At follow-up, four patients had returned to pre-morbid functioning, three had a reduction in functioning attributable to their initial presentation (not NegPH), and one had died of unknown cause. Illustrative case descriptions are included.

Conclusions: Negative-pressure hydrocephalus is a rare but underrecognised syndrome that can be successfully treated by timely external ventricular drainage titrated to maintain CSF flow, and subsequent low-pressure ventriculoperitoneal shunting.

Item Details

Item Type:Refereed Article
Keywords:negative pressure, hydrocephalus, external ventricular drain
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Surgery
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Hunn, BHM (Dr Ben Hunn)
Author:Dubey, AK (Dr Arvind Dubey)
ID Code:94760
Year Published:2014
Web of Science® Times Cited:2
Deposited By:Medicine (Discipline)
Deposited On:2014-09-16
Last Modified:2017-11-02
Downloads:0

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