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Essential oils in the treatment of intestinal dysbiosis: A preliminary in vitro study

journal contribution
posted on 2023-05-18, 03:19 authored by Jason HawrelakJason Hawrelak, Cattley, T, Myers, PM

Introduction: Dysbiosis is associated with a number of gastrointestinal and systemic disorders. There is a need for selectively acting antimicrobial agents capable of inhibiting the growth of potentially pathogenic microorganisms, or those found to be out of balance, while not negatively impacting the bulk gastrointestinal tract microflora.

Objective: The purpose of this in vitro study is to examine the potential of a selection of essential oils as agents to treat dysbiosis.

Materials and Methods: Eight essential oils were examined using the agar dilution method, including Carum carvi, Citrus aurantium var. amara, Foeniculum vulgare dulce, Illicium verum, Lavandula angustifolia, Mentha arvensis, Mentha x piperita, and Trachyspermum copticum. Doubling dilutions of the essential oils were tested against 12 species of intestinal bacteria, which represent the major genera found in the human gastrointestinal tract (GIT).

Results: Carum carvi, Lavandula angustifolia, Trachyspermum copticum, and Citrus aurantium var. amara essential oils displayed the greatest degree of selectivity, inhibiting the growth of potential pathogens at concentrations that had no effect on the beneficial bacteria examined.

Conclusion: The most promising essential oils for the treatment of intestinal dysbiosis are Carum carvi, Lavandula angustifolia, Trachyspermum copticum, and Citrus aurantium var. amara. The herbs from which these oils are derived have long been used in the treatment of gastrointestinal symptoms and the in vitro results of this study suggest that their ingestion will have little detrimental impact on beneficial members of the GIT microflora. More research is needed, however, to investigate tolerability and safety concerns, and verify the selective action of these agents.

History

Publication title

Alternative Medicine Review: A Journal of Clinical Therapeutics

Volume

14

Issue

4

Pagination

380-384

ISSN

1089-5159

Department/School

School of Pharmacy and Pharmacology

Publisher

Thorne Research Inc.

Place of publication

United States

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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